Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Nilotinib | 3 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| BT-20 | Nilotinib | 3 | 625.00 | inf | inf | 1.0387 | 1.0387 | 0.0000 | 1.0488 | flat fit: x = Einf | -187.4768 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| BT-20 | Nilotinib | 3 | 1250.00 | inf | 5.6289 | 0.6127 | 0.6641 | 4.9995 | 0.9908 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8778 | inf | 5.4945 | 0.4630 | 0.5404 | 4.9750 | 0.0289 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9041 |
| BT-20 | Nilotinib | 3 | 2500.00 | 8.5158 | 6.8674 | 0.3395 | 0.3295 | 5.0000 | 0.9520 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9751 | 6.9453 | 7.0079 | -0.0102 | -0.0229 | 5.0000 | 0.0917 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9874 |
| BT-20 | Nilotinib | 3 | 5000.00 | 7.9171 | 6.8469 | 0.2706 | 0.2581 | 5.0000 | 0.9438 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9776 | 6.3355 | 6.9197 | -0.2614 | -0.2772 | 5.0000 | 0.1257 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9913 |
| BT-20 | Taxol | 3 | 156.25 | inf | 0.0023 | 0.4801 | 0.5864 | 4.0329 | 0.7152 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9337 | 0.0025 | 0.0023 | -0.0811 | 0.1314 | 4.2691 | 0.5954 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9502 |
| BT-20 | Taxol | 3 | 312.50 | 0.0095 | 0.0066 | 0.3766 | 0.4156 | 5.0000 | 0.6542 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9756 | 0.0066 | 0.0068 | -0.1639 | -0.0846 | 5.0000 | 0.6440 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9707 |
| BT-20 | Taxol | 3 | 625.00 | 0.0088 | 0.0039 | 0.2707 | 0.3131 | 1.2202 | 0.5653 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9661 | 0.0028 | 0.0038 | -0.2791 | -0.1939 | 1.1242 | 0.7551 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9615 |
| BT-20 | Taxol | 3 | 1250.00 | 0.0066 | 0.0042 | 0.2776 | 0.3056 | 2.0466 | 0.5686 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9934 | 0.0038 | 0.0043 | -0.2030 | -0.1491 | 1.8570 | 0.7091 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9926 |
| BT-20 | Taxol | 3 | 2500.00 | 0.0068 | 0.0052 | 0.2382 | 0.2598 | 2.6837 | 0.5399 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9884 | 0.0052 | 0.0056 | -0.1713 | -0.1253 | 2.6438 | 0.6880 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9902 |
| BT-20 | Taxol | 3 | 5000.00 | 0.0077 | 0.0055 | 0.2679 | 0.2713 | 2.3342 | 0.5512 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9791 | 0.0049 | 0.0059 | -0.2579 | -0.2476 | 2.3414 | 0.7610 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9835 |
| BT-20 | Omipalisib | 3 | 156.25 | 0.0551 | 0.0336 | 0.2307 | 0.3510 | 2.4465 | 0.5933 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9576 | 0.0268 | 0.0342 | -0.5712 | -0.3482 | 2.1648 | 0.8543 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9671 |
| BT-20 | Omipalisib | 3 | 312.50 | 0.0713 | 0.0408 | 0.1241 | 0.2533 | 1.2673 | 0.5486 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9549 | 0.0293 | 0.0491 | -0.6740 | -0.4311 | 1.2077 | 0.8356 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9543 |
| BT-20 | Omipalisib | 3 | 625.00 | 0.0239 | 0.0189 | 0.1128 | 0.1877 | 2.0127 | 0.4216 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9842 | 0.014 | 0.0204 | -0.6344 | -0.4677 | 1.7687 | 1.0271 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9805 |
| BT-20 | Omipalisib | 3 | 1250.00 | 0.0298 | 0.0215 | 0.1005 | 0.1918 | 1.4874 | 0.4440 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9758 | 0.0165 | 0.0271 | -0.6058 | -0.4182 | 1.2221 | 0.9350 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9683 |
| BT-20 | Omipalisib | 3 | 2500.00 | 0.022 | 0.015 | 0.1230 | 0.1735 | 1.1114 | 0.3948 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9847 | 0.0127 | 0.023 | -0.4462 | -0.3580 | 0.9143 | 0.9245 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9739 |
| BT-20 | Omipalisib | 3 | 5000.00 | 0.0197 | 0.0127 | 0.1256 | 0.1826 | 1.0436 | 0.3874 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9855 | 0.0082 | 0.0163 | -0.5787 | -0.4616 | 0.9481 | 1.0528 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9795 |
| BT-20 | Etoposide | 3 | 156.25 | 24.8498 | 16.0883 | 0.5472 | 0.1937 | 1.1268 | 0.9405 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9299 | 8.4612 | 20.2676 | 0.1434 | -0.7260 | 1.0267 | 0.1344 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9568 |
| BT-20 | Etoposide | 3 | 312.50 | inf | 2.7175 | 0.5324 | 0.5362 | 1.8586 | 0.9221 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9614 | 3.3112 | 2.7935 | 0.1316 | 0.1265 | 1.7158 | 0.1693 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9851 |
| BT-20 | Etoposide | 3 | 625.00 | 6.0975 | 2.1561 | 0.4247 | 0.4288 | 1.8746 | 0.8828 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9733 | 2.5827 | 2.3288 | 0.0840 | 0.0841 | 1.7793 | 0.1970 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9868 |
| BT-20 | Etoposide | 3 | 1250.00 | 3.4238 | 1.2638 | 0.3916 | 0.4122 | 1.7456 | 0.8397 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9801 | 1.7161 | 1.4469 | 0.0973 | 0.1204 | 1.6140 | 0.2381 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9879 |
| BT-20 | Etoposide | 3 | 2500.00 | 2.4283 | 1.1042 | 0.3429 | 0.3444 | 1.4816 | 0.8000 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9866 | 1.2701 | 1.2899 | -0.0039 | -0.0110 | 1.4091 | 0.2983 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9918 |
| BT-20 | Etoposide | 3 | 5000.00 | 2.2034 | 0.9445 | 0.3543 | 0.3406 | 1.3495 | 0.7773 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9877 | 0.8879 | 1.05 | -0.0930 | -0.1239 | 1.3204 | 0.3713 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9912 |
| BT-20 | Methotrexate | 3 | 156.25 | inf | inf | 0.9392 | 0.9392 | 0.0000 | 0.9524 | flat fit: x = Einf | 0.2299 | inf | inf | 0.9218 | 0.9218 | 0.0000 | 0.1167 | flat fit: x = Einf | 0.2226 |
| BT-20 | Methotrexate | 3 | 312.50 | inf | inf | 1.0075 | 1.0075 | 0.0000 | 1.0421 | flat fit: x = Einf | -3.507 | inf | inf | 1.0411 | 1.0411 | 0.0000 | -0.0445 | flat fit: x = Einf | -1.1546 |