Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
Hs 578T Lapatinib 10 5000.00
inf
inf
 1.0320 1.0320 0.0000 1.0128
flat fit: x = Einf
-0.3671
inf
inf
 1.0500 1.0500 0.0000 -0.0218
flat fit: x = Einf
-0.2222
Hs 578T Palbociclib 10 156.25
inf
0.5236
 0.4586 0.5976 4.9207 0.8266
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.595
0.6295
0.51
 0.0974 0.3255 4.9994 0.3078
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6074
Hs 578T Palbociclib 10 312.50
0.7445
0.4181
 0.3739 0.4721 5.0000 0.7476
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8727
0.4902
0.3886
 0.1594 0.3435 5.0000 0.3204
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7695
Hs 578T Palbociclib 10 625.00
0.7781
0.5223
 0.4113 0.4319 5.0000 0.7737
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9701
0.6607
0.5808
 0.2067 0.2374 4.9997 0.2969
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9456
Hs 578T Palbociclib 10 1250.00
0.8318
0.4956
 0.4065 0.4205 3.5523 0.7630
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
0.6782
0.6079
 0.1896 0.2107 5.0000 0.3023
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9875
Hs 578T Palbociclib 10 2500.00
1.34
0.2386
 0.4552 0.4373 1.2028 0.7075
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9752
0.3171
0.2355
 0.1802 0.1557 1.2543 0.4349
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9715
Hs 578T Palbociclib 10 5000.00
inf
0.1886
 0.5849 0.5700 1.1185 0.7617
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9781
0.2444
0.1223
 0.2650 0.2205 0.8401 0.4675
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9517
Hs 578T Erlotinib 10 156.25
inf
inf
 0.9057 0.9057 0.0000 1.0124
flat fit: x = Einf
0.0408
inf
inf
 0.9133 0.9133 0.0000 -0.0099
flat fit: x = Einf
0.07
Hs 578T Erlotinib 10 312.50
inf
5.2298
 0.6499 0.6463 3.7026 0.9450
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9506
inf
5.4209
 0.7081 0.7048 3.6547 0.0446
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9496
Hs 578T Erlotinib 10 625.00
inf
5.3225
 0.5938 0.5831 2.7491 0.9457
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9816
inf
5.8379
 0.6532 0.6399 2.6469 0.0453
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9849
Hs 578T Erlotinib 10 1250.00
62.7278
14.2382
 0.6532 0.4352 1.3779 0.9517
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9872
63.6023
16.4988
 0.6733 0.4221 1.3777 0.0434
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9898
Hs 578T Erlotinib 10 2500.00
inf
11.3892
 0.8171 0.7174 1.1581 0.9672
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9719
inf
11.0399
 0.7413 0.6085 1.1980 0.0458
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9731
Hs 578T Erlotinib 10 5000.00
inf
2.1621
 0.9335 0.9364 1.1662 0.9868
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9223
inf
2.0403
 0.7673 0.7803 1.2187 0.0461
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9184
Hs 578T Nilotinib 10 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0456
flat fit: x = Einf
-20.0621
inf
inf
 1.0500 1.0500 0.0000 -0.0294
flat fit: x = Einf
-0.4469
Hs 578T Nilotinib 10 312.50
inf
inf
 0.8067 0.8067 0.0000 0.9783
flat fit: x = Einf
0.3176
inf
inf
 0.7883 0.7883 0.0000 0.0295
flat fit: x = Einf
0.3398
Hs 578T Nilotinib 10 625.00
inf
inf
 0.5300 0.5300 0.0000 0.9398
flat fit: x = Einf
0.4791
inf
inf
 0.3892 0.3892 0.0000 0.0676
flat fit: x = Einf
0.4455
Hs 578T Nilotinib 10 1250.00
inf
2.4741
 0.4010 0.6831 5.0000 0.9386
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5606
inf
inf
 0.1638 0.1638 0.0000 0.0901
flat fit: x = Einf
0.4461
Hs 578T Nilotinib 10 2500.00
5.8281
3.037
 0.4063 0.4808 5.0000 0.9137
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9548
3.6188
3.1994
 0.0907 0.2299 5.0000 0.1378
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9507
Hs 578T Nilotinib 10 5000.00
10.2134
4.8119
 0.4948 0.4884 5.0000 0.9372
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9865
6.3683
6.3032
 0.0527 0.0250 5.0000 0.0923
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9848
Hs 578T Taxol 10 156.25
0.0085
0.0027
 0.3166 0.4093 1.4983 0.6123
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9624
0.0048
0.0046
 -0.1603 0.0291 1.4708 0.5816
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9429
Hs 578T Taxol 10 312.50
0.0031
0.0017
 0.3003 0.3546 1.9508 0.5348
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9729
0.0023
0.0021
 0.0213 0.1238 2.2694 0.6112
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9693
Hs 578T Taxol 10 625.00
0.0024
0.0016
 0.2857 0.3173 2.4716 0.5023
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9928
0.0019
0.0018
 -0.0429 0.0149 2.4087 0.7044
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9933
Hs 578T Taxol 10 1250.00
0.0037
0.0024
 0.2780 0.3028 2.1105 0.5228
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9905
0.0026
0.0027
 -0.0590 -0.0216 1.7221 0.6835
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9886
Hs 578T Taxol 10 2500.00
0.0059
0.0037
 0.3076 0.3369 2.4707 0.5908
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9848
0.0039
0.0041
 -0.0932 -0.0471 2.1128 0.6414
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9878
Hs 578T Taxol 10 5000.00
0.0225
0.0083
 0.4268 0.4762 3.0421 0.7270
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9783
0.0088
0.0089
 -0.1238 -0.0131 3.2418 0.5230
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9737