LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1209 | 527 | 4203 | 0.1258 | -0.3701 |
| MCF 10A | BMS345541 | 3.33 | uM | LJP6 | 72 | hr | 962 | 10231 | 10692 | 0.9569 | 0.9748 |
| SK-BR-3 | WH-4-025 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4040 | 4245 | 0.9601 | 0.9525 |
| SK-BR-3 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 4313 | 4168 | 1.0368 | 1.0452 |
| MCF 10A | PLX-4720 | 3.33 | uM | LJP5 | 72 | hr | 962 | 9312 | 10512 | 0.8860 | 0.9309 |
| MCF7 | Crizotinib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1299 | 4203 | 0.3095 | 0.0403 |
| MDA-MB-231 | NU7441 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2712 | 4660 | 0.5852 | 0.5096 |
| SK-BR-3 | BI-2536 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 1282 | 4168 | 0.3077 | -0.0551 |
| SK-BR-3 | Nintedanib | 3.33 | uM | LJP6 | 72 | hr | 1401 | 3279 | 4168 | 0.7872 | 0.7179 |
| SK-BR-3 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 984 | 4168 | 0.2361 | -0.2020 |
| MDA-MB-231 | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 497 | 4405 | 0.1131 | -0.3916 |
| MCF7 | Radicicol | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1429 | 4203 | 0.3410 | 0.0971 |
| MDA-MB-231 | AZD-6482 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 3381 | 4660 | 0.7251 | 0.6898 |
| SK-BR-3 | SB590885 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4570 | 4245 | 1.0746 | 1.0901 |
| MDA-MB-231 | HG-5-88-01 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 4042 | 4405 | 0.9164 | 0.9057 |
| MCF7 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1209 | 3423 | 4012 | 0.8506 | 0.8168 |
| SK-BR-3 | Pictilisib | 3.33 | uM | LJP6 | 72 | hr | 1401 | 1576 | 4168 | 0.3780 | 0.0772 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 809 | 4168 | 0.1942 | -0.2949 |
| MCF 10A | KIN001-043 | 3.33 | uM | LJP6 | 72 | hr | 962 | 8700 | 10692 | 0.8138 | 0.8846 |
| MDA-MB-231 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 3454 | 4405 | 0.7849 | 0.7523 |
| SK-BR-3 | PD184352 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4447 | 4245 | 1.0482 | 1.0601 |
| SK-BR-3 | Foretinib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 1485 | 4245 | 0.3500 | 0.0351 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 1086 | 4245 | 0.2561 | -0.1492 |
| SK-BR-3 | PLX-4720 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 3476 | 4245 | 0.8069 | 0.7202 |
| MCF 10A | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 962 | 1609 | 10512 | 0.1532 | 0.1608 |