LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | ZSTK474 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1337 | 4056 | 0.3299 | 0.0476 |
| MCF7 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1270 | 4056 | 0.3134 | 0.0165 |
| MCF7 | ZSTK474 | 10 | uM | LJP6 | 72 | hr | 1235 | 1338 | 4056 | 0.3303 | 0.0476 |
| MCF7 | BX-912 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 3458 | 4267 | 0.8088 | 0.7728 |
| MCF7 | BX-912 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 3692 | 4267 | 0.8657 | 0.8453 |
| MCF7 | BX-912 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 3339 | 4267 | 0.7824 | 0.7432 |
| MCF7 | BX-912 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2350 | 4267 | 0.5517 | 0.4334 |
| MCF7 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1930 | 4267 | 0.4528 | 0.2839 |
| MCF7 | BX-912 | 10 | uM | LJP5 | 72 | hr | 1235 | 1281 | 4267 | 0.3002 | 0.0199 |
| MCF7 | Selumetinib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 3986 | 4056 | 0.9833 | 0.9788 |
| MCF7 | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 3193 | 4056 | 0.7886 | 0.7389 |
| MCF7 | Selumetinib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 2879 | 4056 | 0.7104 | 0.6371 |
| MCF7 | Selumetinib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 2833 | 4056 | 0.6990 | 0.6213 |
| MCF7 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 2821 | 4056 | 0.6951 | 0.6167 |
| MCF7 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 1235 | 2601 | 4056 | 0.6416 | 0.5438 |
| MCF7 | MK2206 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 2855 | 4056 | 0.7032 | 0.6279 |
| MCF7 | MK2206 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 2395 | 4056 | 0.5902 | 0.4702 |
| MCF7 | MK2206 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1620 | 4056 | 0.3990 | 0.1699 |
| MCF7 | MK2206 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1659 | 4056 | 0.4087 | 0.1868 |
| MCF7 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1414 | 4056 | 0.3483 | 0.0800 |
| MCF7 | MK2206 | 10 | uM | LJP6 | 72 | hr | 1235 | 733 | 4056 | 0.1806 | -0.2633 |
| MCF7 | AZD-6482 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4799 | 4267 | 1.1252 | 1.1369 |
| MCF7 | AZD-6482 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 3850 | 4267 | 0.9019 | 0.8873 |
| MCF7 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4040 | 4267 | 0.9481 | 0.9414 |
| MCF7 | AZD-6482 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4006 | 4267 | 0.9390 | 0.9309 |