LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1035 | 4267 | 0.2429 | -0.0941 |
| MCF 10A | BMS345541 | 3.33 | uM | LJP6 | 72 | hr | 513 | 9529 | 10473 | 0.9097 | 0.9567 |
| SK-BR-3 | WH-4-025 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 2686 | 3772 | 0.7120 | 0.5556 |
| SK-BR-3 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4220 | 3643 | 1.1605 | 1.2471 |
| MCF 10A | PLX-4720 | 3.33 | uM | LJP5 | 72 | hr | 513 | 10721 | 10362 | 1.0349 | 1.0157 |
| MCF7 | Crizotinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1243 | 4267 | 0.2913 | 0.0030 |
| MDA-MB-231 | NU7441 | 3.33 | uM | LJP5 | 72 | hr | 868 | 1978 | 3410 | 0.5812 | 0.5183 |
| SK-BR-3 | BI-2536 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1426 | 3643 | 0.3925 | -0.0259 |
| SK-BR-3 | Nintedanib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 2580 | 3643 | 0.7096 | 0.5372 |
| SK-BR-3 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1070 | 3643 | 0.2936 | -0.2211 |
| MDA-MB-231 | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 868 | 683 | 3556 | 0.1921 | -0.1122 |
| MCF7 | Radicicol | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1664 | 4267 | 0.3900 | 0.1808 |
| MDA-MB-231 | AZD-6482 | 3.33 | uM | LJP5 | 72 | hr | 868 | 1993 | 3410 | 0.5836 | 0.5195 |
| SK-BR-3 | SB590885 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 4121 | 3772 | 1.0927 | 1.1356 |
| MDA-MB-231 | HG-5-88-01 | 3.33 | uM | LJP6 | 72 | hr | 868 | 2204 | 3556 | 0.6207 | 0.5819 |
| MCF7 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 3842 | 4056 | 0.9477 | 0.9381 |
| SK-BR-3 | Pictilisib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1669 | 3643 | 0.4590 | 0.0987 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 852 | 3643 | 0.2335 | -0.3474 |
| MCF 10A | KIN001-043 | 3.33 | uM | LJP6 | 72 | hr | 513 | 6085 | 10473 | 0.5809 | 0.7645 |
| MDA-MB-231 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 868 | 2585 | 3556 | 0.7262 | 0.7080 |
| SK-BR-3 | PD184352 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 3597 | 3772 | 0.9537 | 0.9311 |
| SK-BR-3 | Foretinib | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1454 | 3772 | 0.3857 | -0.0110 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1041 | 3772 | 0.2760 | -0.2278 |
| SK-BR-3 | PLX-4720 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 2775 | 3772 | 0.7359 | 0.5934 |
| MCF 10A | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 513 | 1326 | 10362 | 0.1280 | 0.2446 |