LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | Gefitinib | 0.04 | uM | LJP6 | 72 | hr | 868 | 4066 | 3556 | 1.1438 | 1.1368 |
| BT-20 | Enzastaurin | 1.11 | uM | LJP5 | 72 | hr | 1657 | 6392 | 5588 | 1.1441 | 1.1597 |
| MCF7 | SU11274 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4880 | 4267 | 1.1441 | 1.1561 |
| Hs 578T | Nilotinib | 0.37 | uM | LJP5 | 72 | hr | 929 | 3705 | 3237 | 1.1445 | 1.1555 |
| SK-BR-3 | Saracatinib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 4158 | 3643 | 1.1448 | 1.2253 |
| MCF7 | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4899 | 4267 | 1.1480 | 1.1604 |
| MDA-MB-231 | PD173074 | 0.04 | uM | LJP6 | 72 | hr | 868 | 4084 | 3556 | 1.1488 | 1.1413 |
| SK-BR-3 | SU11274 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4337 | 3772 | 1.1497 | 1.2170 |
| SK-BR-3 | XL147 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 4341 | 3772 | 1.1507 | 1.2181 |
| MCF7 | Pelitinib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4915 | 4267 | 1.1518 | 1.1635 |
| MCF7 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4925 | 4267 | 1.1553 | 1.1686 |
| MCF7 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4692 | 4056 | 1.1566 | 1.1765 |
| MCF7 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4937 | 4267 | 1.1567 | 1.1690 |
| SK-BR-3 | R406 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 4206 | 3643 | 1.1578 | 1.2443 |
| SK-BR-3 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4220 | 3643 | 1.1605 | 1.2471 |
| SK-BR-3 | Saracatinib | 0.04 | uM | LJP6 | 72 | hr | 1476 | 4233 | 3643 | 1.1657 | 1.2572 |
| Hs 578T | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 929 | 3750 | 3216 | 1.1660 | 1.1789 |
| Hs 578T | PLX-4720 | 1.11 | uM | LJP5 | 72 | hr | 929 | 3783 | 3237 | 1.1683 | 1.1803 |
| Hs 578T | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 929 | 3785 | 3237 | 1.1691 | 1.1812 |
| Hs 578T | SB590885 | 0.12 | uM | LJP5 | 72 | hr | 929 | 3796 | 3237 | 1.1726 | 1.1849 |
| SK-BR-3 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 4269 | 3643 | 1.1728 | 1.2634 |
| Hs 578T | Sorafenib | 0.04 | uM | LJP6 | 72 | hr | 929 | 3783 | 3216 | 1.1761 | 1.1895 |
| MCF7 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 5022 | 4267 | 1.1763 | 1.1893 |
| SK-BR-3 | PD173074 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 4293 | 3643 | 1.1784 | 1.2700 |
| BT-20 | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 1657 | 6589 | 5588 | 1.1796 | 1.1970 |