LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 929 | 3387 | 3237 | 1.0461 | 1.0506 |
| BT-20 | NVP-AEW541 | 3.33 | uM | LJP5 | 72 | hr | 1657 | 5837 | 5588 | 1.0449 | 1.0507 |
| BT-20 | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 1657 | 5842 | 5588 | 1.0453 | 1.0508 |
| MDA-MB-231 | PD184352 | 0.04 | uM | LJP5 | 72 | hr | 868 | 3587 | 3410 | 1.0514 | 1.0513 |
| MDA-MB-231 | NVP-AEW541 | 0.37 | uM | LJP5 | 72 | hr | 868 | 3583 | 3410 | 1.0521 | 1.0514 |
| SK-BR-3 | NVP-AEW541 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 3906 | 3772 | 1.0356 | 1.0517 |
| MCF7 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4461 | 4267 | 1.0484 | 1.0518 |
| MDA-MB-231 | PHA-665752 | 0.04 | uM | LJP5 | 72 | hr | 868 | 3586 | 3410 | 1.0523 | 1.0523 |
| BT-20 | CP466722 | 0.37 | uM | LJP5 | 72 | hr | 1657 | 5847 | 5588 | 1.0463 | 1.0523 |
| SK-BR-3 | Withaferin A | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3774 | 3643 | 1.0354 | 1.0527 |
| MDA-MB-231 | Imatinib | 1.11 | uM | LJP6 | 72 | hr | 868 | 3756 | 3556 | 1.0557 | 1.0533 |
| MCF 10A | Celastrol | 0.12 | uM | LJP6 | 72 | hr | 513 | 11759 | 10473 | 1.1230 | 1.0538 |
| MDA-MB-231 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 868 | 3598 | 3410 | 1.0547 | 1.0539 |
| MDA-MB-231 | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 868 | 3606 | 3410 | 1.0563 | 1.0541 |
| MDA-MB-231 | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 868 | 3755 | 3556 | 1.0560 | 1.0543 |
| BT-20 | Imatinib | 1.11 | uM | LJP6 | 72 | hr | 1657 | 5631 | 5383 | 1.0467 | 1.0550 |
| Hs 578T | KIN001-043 | 0.37 | uM | LJP6 | 72 | hr | 929 | 3379 | 3216 | 1.0505 | 1.0556 |
| MCF7 | Y39983 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4249 | 4056 | 1.0481 | 1.0557 |
| Hs 578T | CP466722 | 1.11 | uM | LJP5 | 72 | hr | 929 | 3402 | 3237 | 1.0509 | 1.0560 |
| BT-20 | Saracatinib | 0.04 | uM | LJP6 | 72 | hr | 1657 | 5648 | 5383 | 1.0488 | 1.0562 |
| SK-BR-3 | BMS345541 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 3784 | 3643 | 1.0379 | 1.0568 |
| MDA-MB-231 | SU11274 | 0.37 | uM | LJP5 | 72 | hr | 868 | 3611 | 3410 | 1.0585 | 1.0583 |
| MDA-MB-231 | PLX-4720 | 0.12 | uM | LJP5 | 72 | hr | 868 | 3613 | 3410 | 1.0591 | 1.0585 |
| MCF7 | PHA-665752 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4485 | 4267 | 1.0528 | 1.0586 |
| SK-BR-3 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 3923 | 3772 | 1.0402 | 1.0591 |