LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Sorafenib | 1.11 | uM | LJP6 | 72 | hr | 929 | 4060 | 3216 | 1.2624 | 1.2779 |
| SK-BR-3 | PD173074 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 4309 | 3643 | 1.1824 | 1.2748 |
| SK-BR-3 | PD173074 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 4293 | 3643 | 1.1784 | 1.2700 |
| SK-BR-3 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 4479 | 3772 | 1.1871 | 1.2687 |
| SK-BR-3 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 4269 | 3643 | 1.1728 | 1.2634 |
| SK-BR-3 | Saracatinib | 0.04 | uM | LJP6 | 72 | hr | 1476 | 4233 | 3643 | 1.1657 | 1.2572 |
| BT-20 | Enzastaurin | 10 | uM | LJP5 | 72 | hr | 1657 | 6867 | 5588 | 1.2290 | 1.2497 |
| SK-BR-3 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4220 | 3643 | 1.1605 | 1.2471 |
| SK-BR-3 | R406 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 4206 | 3643 | 1.1578 | 1.2443 |
| Hs 578T | Sorafenib | 0.37 | uM | LJP6 | 72 | hr | 929 | 3923 | 3216 | 1.2199 | 1.2347 |
| Hs 578T | SB590885 | 3.33 | uM | LJP5 | 72 | hr | 929 | 3939 | 3237 | 1.2167 | 1.2301 |
| Hs 578T | Sorafenib | 3.33 | uM | LJP6 | 72 | hr | 929 | 3894 | 3216 | 1.2107 | 1.2253 |
| SK-BR-3 | Saracatinib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 4158 | 3643 | 1.1448 | 1.2253 |
| Hs 578T | SB590885 | 0.04 | uM | LJP5 | 72 | hr | 929 | 3913 | 3237 | 1.2087 | 1.2219 |
| SK-BR-3 | XL147 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 4341 | 3772 | 1.1507 | 1.2181 |
| Hs 578T | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 929 | 3899 | 3237 | 1.2045 | 1.2177 |
| SK-BR-3 | SU11274 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4337 | 3772 | 1.1497 | 1.2170 |
| MCF7 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 4840 | 4056 | 1.1932 | 1.2169 |
| MCF7 | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4834 | 4056 | 1.1918 | 1.2152 |
| SK-BR-3 | R406 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4165 | 3643 | 1.1424 | 1.2146 |
| BT-20 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1657 | 6376 | 5383 | 1.1852 | 1.2109 |
| BT-20 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1657 | 6371 | 5383 | 1.1849 | 1.2102 |
| SK-BR-3 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 4313 | 3772 | 1.1433 | 1.2076 |
| SK-BR-3 | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 4118 | 3643 | 1.1322 | 1.2035 |
| MCF7 | Linifanib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4787 | 4056 | 1.1804 | 1.2033 |