LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 513 | 132 | 10362 | 0.0128 | -0.2695 |
| MCF 10A | Dasatinib | 10 | uM | LJP6 | 72 | hr | 513 | 217 | 10473 | 0.0207 | -0.1805 |
| MCF 10A | Canertinib | 10 | uM | LJP6 | 72 | hr | 513 | 223 | 10473 | 0.0213 | -0.1849 |
| MCF 10A | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 513 | 246 | 10473 | 0.0235 | -0.1572 |
| MCF 10A | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 513 | 262 | 10473 | 0.0250 | -0.1442 |
| MCF 10A | GSK1059615 | 10 | uM | LJP5 | 72 | hr | 513 | 283 | 10362 | 0.0273 | -0.1286 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 868 | 290 | 3556 | 0.0816 | -0.4170 |
| MCF 10A | Dasatinib | 3.33 | uM | LJP6 | 72 | hr | 513 | 305 | 10473 | 0.0291 | -0.1141 |
| MCF 10A | Geldanamycin | 10 | uM | LJP5 | 72 | hr | 513 | 307 | 10362 | 0.0297 | -0.1119 |
| MCF 10A | GSK1059615 | 10 | uM | LJP6 | 72 | hr | 513 | 317 | 10473 | 0.0302 | -0.1063 |
| MCF 10A | Withaferin A | 10 | uM | LJP5 | 72 | hr | 513 | 321 | 10362 | 0.0310 | -0.1046 |
| MCF 10A | Withaferin A | 10 | uM | LJP6 | 72 | hr | 513 | 325 | 10473 | 0.0310 | -0.1050 |
| MCF 10A | Buparlisib | 10 | uM | LJP5 | 72 | hr | 513 | 331 | 10362 | 0.0320 | -0.0963 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 868 | 331 | 3410 | 0.0969 | -0.3874 |
| MCF 10A | Dasatinib | 10 | uM | LJP5 | 72 | hr | 513 | 332 | 10362 | 0.0320 | -0.0967 |
| MDA-MB-231 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 868 | 332 | 3410 | 0.0973 | -0.3860 |
| MCF 10A | Dasatinib | 3.33 | uM | LJP5 | 72 | hr | 513 | 337 | 10362 | 0.0325 | -0.0932 |
| MCF 10A | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 513 | 345 | 10473 | 0.0330 | -0.0882 |
| MCF 10A | Radicicol | 10 | uM | LJP5 | 72 | hr | 513 | 347 | 10362 | 0.0336 | -0.0877 |
| MCF 10A | GSK1059615 | 3.33 | uM | LJP5 | 72 | hr | 513 | 348 | 10362 | 0.0336 | -0.0875 |
| MCF 10A | A443654 | 3.33 | uM | LJP6 | 72 | hr | 513 | 351 | 10473 | 0.0335 | -0.0835 |
| MCF 10A | Afatinib | 0.04 | uM | LJP6 | 72 | hr | 513 | 351 | 10473 | 0.0335 | -0.0847 |
| MCF 10A | AZD7762 | 10 | uM | LJP6 | 72 | hr | 513 | 353 | 10473 | 0.0338 | -0.0823 |
| MCF 10A | QL-X-138 | 10 | uM | LJP6 | 72 | hr | 513 | 363 | 10473 | 0.0347 | -0.0771 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 513 | 371 | 10362 | 0.0358 | -0.0722 |