LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | R406 | 10.0 | uM | LJP6 | 72 | hr | 962 | 5513 | 10605 | 0.5199 | 0.4720 |
| MCF 10A | Pictilisib | 10.0 | uM | LJP6 | 72 | hr | 962 | 1286 | 10605 | 0.1213 | 0.0336 |
| MCF 10A | Gefitinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 1262 | 10605 | 0.1191 | 0.0312 |
| MCF 10A | Geldanamycin | 10.0 | uM | LJP5 | 72 | hr | 962 | 672 | 10605 | 0.0634 | -0.0301 |
| MCF 10A | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 962 | 393 | 10605 | 0.0371 | -0.0590 |
| MCF 10A | GSK1059615 | 10.0 | uM | LJP5 | 72 | hr | 962 | 480 | 10605 | 0.0453 | -0.0500 |
| MCF 10A | GSK1059615 | 10.0 | uM | LJP6 | 72 | hr | 962 | 491 | 10605 | 0.0464 | -0.0488 |
| MCF 10A | GSK1904529A | 10.0 | uM | LJP6 | 72 | hr | 962 | 7685 | 10605 | 0.7247 | 0.6972 |
| MCF 10A | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 962 | 720 | 10605 | 0.0680 | -0.0250 |
| MCF 10A | GSK 690693 | 10.0 | uM | LJP5 | 72 | hr | 962 | 8706 | 10605 | 0.8209 | 0.8031 |
| MCF 10A | GW843682X | 10.0 | uM | LJP6 | 72 | hr | 962 | 661 | 10605 | 0.0624 | -0.0312 |
| MCF 10A | HG-5-113-01 | 10.0 | uM | LJP5 | 72 | hr | 962 | 836 | 10605 | 0.0788 | -0.0131 |
| MCF 10A | HG-5-88-01 | 10.0 | uM | LJP6 | 72 | hr | 962 | 3772 | 10605 | 0.3557 | 0.2915 |
| MCF 10A | Imatinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 10038 | 10605 | 0.9465 | 0.9412 |
| MCF 10A | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 962 | 722 | 10605 | 0.0681 | -0.0249 |
| MCF 10A | JW-7-24-1 | 10.0 | uM | LJP6 | 72 | hr | 962 | 1460 | 10605 | 0.1377 | 0.0516 |
| MCF 10A | Lapatinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 2659 | 10605 | 0.2508 | 0.1760 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 962 | 136 | 10605 | 0.0128 | -0.0857 |
| MCF 10A | Linifanib | 10.0 | uM | LJP6 | 72 | hr | 962 | 7918 | 10605 | 0.7467 | 0.7214 |
| MCF 10A | Linsitinib | 10.0 | uM | LJP5 | 72 | hr | 962 | 8613 | 10605 | 0.8122 | 0.7934 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 962 | 509 | 10605 | 0.0480 | -0.0470 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 962 | 552 | 10605 | 0.0521 | -0.0425 |
| MCF 10A | MK2206 | 10.0 | uM | LJP6 | 72 | hr | 962 | 2924 | 10605 | 0.2758 | 0.2035 |
| MCF 10A | Neratinib | 10.0 | uM | LJP5 | 72 | hr | 962 | 1606 | 10605 | 0.1515 | 0.0668 |
| MCF 10A | Nilotinib | 10.0 | uM | LJP5 | 72 | hr | 962 | 2718 | 10605 | 0.2564 | 0.1822 |