LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Selumetinib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2916 | 11155 | 0.2614 | 0.1291 |
| MCF 10A | Sirolimus | 10.0 | uM | LJP6 | 72 | hr | 1694 | 12441 | 11155 | 1.1152 | 1.1359 |
| MCF 10A | Sorafenib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 6560 | 11155 | 0.5880 | 0.5143 |
| MCF 10A | SU11274 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 5191 | 11155 | 0.4654 | 0.3696 |
| MCF 10A | Fedratinib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 2149 | 11155 | 0.1927 | 0.0481 |
| MCF 10A | TGX221 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 11120 | 11155 | 0.9968 | 0.9962 |
| MCF 10A | Torin1 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2056 | 11155 | 0.1844 | 0.0383 |
| MCF 10A | Torin2 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 1706 | 11155 | 0.1530 | 0.0013 |
| MCF 10A | Tozasertib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 1746 | 11155 | 0.1566 | 0.0055 |
| MCF 10A | Trametinib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 3367 | 11155 | 0.3019 | 0.1768 |
| MCF 10A | TWS119 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 2114 | 11155 | 0.1896 | 0.0444 |
| MCF 10A | Vemurafenib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 5157 | 11155 | 0.4623 | 0.3661 |
| MCF 10A | Withaferin A | 10.0 | uM | LJP5 | 72 | hr | 1694 | 297 | 11155 | 0.0267 | -0.1476 |
| MCF 10A | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 1694 | 241 | 11155 | 0.0216 | -0.1536 |
| MCF 10A | WYE-125132 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2598 | 11155 | 0.2330 | 0.0956 |
| MCF 10A | WZ3105 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 371 | 11155 | 0.0333 | -0.1398 |
| MCF 10A | XMD11-50 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2551 | 11155 | 0.2287 | 0.0906 |
| MCF 10A | Y39983 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 3290 | 11155 | 0.2949 | 0.1687 |
| MCF 10A | YM 201636 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 3469 | 11155 | 0.3110 | 0.1876 |
| MCF 10A | ZSTK474 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2788 | 11155 | 0.2500 | 0.1156 |
| MCF7 | Afatinib | 0.04 | uM | LJP6 | 72 | hr | 1389 | 4541 | 5667 | 0.8013 | 0.7368 |
| MCF7 | Sigma A6730 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 4389 | 5667 | 0.7745 | 0.7012 |
| MCF7 | Alvocidib | 0.04 | uM | LJP6 | 72 | hr | 1389 | 1631 | 5667 | 0.2878 | 0.0565 |
| MCF7 | AT-7519 | 0.04 | uM | LJP6 | 72 | hr | 1389 | 5420 | 5667 | 0.9563 | 0.9421 |
| MCF7 | AZD 5438 | 0.04 | uM | LJP6 | 72 | hr | 1389 | 4843 | 5667 | 0.8545 | 0.8072 |