LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 1389 | 3098 | 5667 | 0.5466 | 0.3995 |
| MCF7 | Sirolimus | 3.33 | uM | LJP6 | 72 | hr | 1389 | 3196 | 5667 | 0.5640 | 0.4225 |
| MCF7 | Sorafenib | 3.33 | uM | LJP6 | 72 | hr | 1389 | 4391 | 5667 | 0.7748 | 0.7017 |
| MCF7 | SU11274 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 4553 | 5667 | 0.8034 | 0.7396 |
| MCF7 | Fedratinib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2122 | 5667 | 0.3744 | 0.1713 |
| MCF7 | TGX221 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 4176 | 5667 | 0.7369 | 0.6515 |
| MCF7 | Torin1 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1459 | 5667 | 0.2574 | 0.0163 |
| MCF7 | Torin2 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1322 | 5667 | 0.2332 | -0.0157 |
| MCF7 | Tozasertib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1530 | 5667 | 0.2700 | 0.0331 |
| MCF7 | Trametinib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2929 | 5667 | 0.5168 | 0.3599 |
| MCF7 | TWS119 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 4120 | 5667 | 0.7269 | 0.6382 |
| MCF7 | Vemurafenib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 5927 | 5667 | 1.0458 | 1.0607 |
| MCF7 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1031 | 5667 | 0.1820 | -0.0836 |
| MCF7 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1049 | 5667 | 0.1851 | -0.0794 |
| MCF7 | WYE-125132 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1701 | 5667 | 0.3002 | 0.0730 |
| MCF7 | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 614 | 5667 | 0.1084 | -0.1810 |
| MCF7 | XMD11-50 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 2022 | 5667 | 0.3568 | 0.1480 |
| MCF7 | Y39983 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 3883 | 5667 | 0.6851 | 0.5829 |
| MCF7 | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 3105 | 5667 | 0.5479 | 0.4011 |
| MCF7 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1571 | 5667 | 0.2773 | 0.0427 |
| MCF7 | Afatinib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 760 | 5667 | 0.1342 | -0.1469 |
| MCF7 | Sigma A6730 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 1919 | 5667 | 0.3387 | 0.1240 |
| MCF7 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 509 | 5667 | 0.0898 | -0.2057 |
| MCF7 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 344 | 5667 | 0.0607 | -0.2442 |
| MCF7 | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 297 | 5667 | 0.0524 | -0.2552 |