PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 24 | hr | p27 Kip1 | -6.63380 | 0.73834 |
| MZ7-mel | 48 | hr | p-p90RSK(S380) | -0.04724 | 2.49950 |
| MZ7-mel | 48 | hr | p-p90RSK(T573) | 7.21660 | -0.24337 |
| MZ7-mel | 48 | hr | p-AKT(T308) | -2.88360 | 1.08770 |
| MZ7-mel | 48 | hr | p-AKT(S473) | -1.25220 | 2.14980 |
| MZ7-mel | 48 | hr | p-mTOR(S2448) | -4.76650 | 2.94890 |
| MZ7-mel | 48 | hr | p-p70S6K(T421/S424) | 2.78950 | 1.36190 |
| MZ7-mel | 48 | hr | p-p70S6K(T389) | -1.84640 | 0.53493 |
| MZ7-mel | 48 | hr | p-S6(S235/236) | 4.30020 | -1.22090 |
| MZ7-mel | 48 | hr | p-AMPK(T172) | -0.74326 | 2.48220 |
| MZ7-mel | 48 | hr | p-JNK(T183/Y185) | -1.19750 | 2.45520 |
| MZ7-mel | 48 | hr | Total c-Jun | -0.60765 | 2.15120 |
| MZ7-mel | 48 | hr | p-cJun(S63) | -3.21440 | 2.82590 |
| MZ7-mel | 48 | hr | p-P38(T180/Y182) | 2.43980 | 2.88760 |
| MZ7-mel | 48 | hr | p-HSP27(S82) | -2.61480 | 2.20550 |
| MZ7-mel | 48 | hr | p-NFKB(S536) | -1.05860 | 1.11740 |
| MZ7-mel | 48 | hr | Bim | -7.96560 | 2.16190 |
| MZ7-mel | 48 | hr | cPARP | -7.02990 | 3.35310 |
| MZ7-mel | 48 | hr | p-Histone H3(S10) | 10.26000 | -2.89720 |
| MZ7-mel | 48 | hr | p27 Kip1 | -7.50270 | 3.06240 |
| RVH-421 | 1 | hr | p-p90RSK(S380) | 1.58200 | -0.54726 |
| RVH-421 | 1 | hr | p-p90RSK(T573) | 1.56040 | -1.73610 |
| RVH-421 | 1 | hr | p-AKT(T308) | 1.96230 | -1.52750 |
| RVH-421 | 1 | hr | p-AKT(S473) | 0.99553 | -0.71683 |
| RVH-421 | 1 | hr | p-mTOR(S2448) | 2.19660 | -1.43330 |