PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 10 | hr | p-AKT(T308) | -1.31350 | 2.68290 |
| WM-115 | 10 | hr | p-AKT(S473) | -1.44710 | 1.57620 |
| WM-115 | 10 | hr | p-mTOR(S2448) | 0.63603 | 1.35530 |
| WM-115 | 10 | hr | p-p70S6K(T421/S424) | 1.02830 | 1.02420 |
| WM-115 | 10 | hr | p-p70S6K(T389) | 1.75460 | 1.61480 |
| WM-115 | 10 | hr | p-S6(S235/236) | 3.14820 | -1.06610 |
| WM-115 | 10 | hr | p-AMPK(T172) | 0.70271 | 1.29880 |
| WM-115 | 10 | hr | p-JNK(T183/Y185) | 1.17530 | 1.72390 |
| WM-115 | 10 | hr | Total c-Jun | -0.96751 | -0.38943 |
| WM-115 | 10 | hr | p-cJun(S63) | 0.13867 | 2.07720 |
| WM-115 | 10 | hr | p-P38(T180/Y182) | 0.68764 | 0.50205 |
| WM-115 | 10 | hr | p-HSP27(S82) | -0.65207 | 0.53060 |
| WM-115 | 10 | hr | p-NFKB(S536) | 0.49059 | 1.12930 |
| WM-115 | 10 | hr | Bim | -0.47370 | 2.53140 |
| WM-115 | 10 | hr | cPARP | 0.09861 | 0.71744 |
| WM-115 | 10 | hr | p-Histone H3(S10) | -2.44350 | 1.83280 |
| WM-115 | 10 | hr | p27 Kip1 | 0.13269 | 1.08210 |
| WM-115 | 24 | hr | p-p90RSK(S380) | 0.04883 | 0.57155 |
| WM-115 | 24 | hr | p-p90RSK(T573) | -0.14672 | 1.10370 |
| WM-115 | 24 | hr | p-AKT(T308) | -1.36980 | 2.28720 |
| WM-115 | 24 | hr | p-AKT(S473) | -1.54260 | 1.88280 |
| WM-115 | 24 | hr | p-mTOR(S2448) | -0.66547 | 2.25240 |
| WM-115 | 24 | hr | p-p70S6K(T421/S424) | -0.99170 | 0.93362 |
| WM-115 | 24 | hr | p-p70S6K(T389) | -1.73140 | 2.04810 |
| WM-115 | 24 | hr | p-S6(S235/236) | 5.90130 | -1.65730 |