PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 1 | hr | Bim | 2.07880 | 2.03290 |
| WM-115 | 1 | hr | cPARP | 1.02760 | 1.05030 |
| WM-115 | 1 | hr | p-Histone H3(S10) | 0.40731 | 1.46970 |
| WM-115 | 1 | hr | p27 Kip1 | 1.29790 | 1.74880 |
| WM-115 | 5 | hr | p-p90RSK(S380) | 2.09450 | 0.73693 |
| WM-115 | 5 | hr | p-p90RSK(T573) | -0.34842 | 0.20924 |
| WM-115 | 5 | hr | p-AKT(T308) | -3.07290 | 2.99210 |
| WM-115 | 5 | hr | p-AKT(S473) | -2.44460 | 1.45070 |
| WM-115 | 5 | hr | p-mTOR(S2448) | -0.03264 | 1.27090 |
| WM-115 | 5 | hr | p-p70S6K(T421/S424) | -0.41538 | 1.24380 |
| WM-115 | 5 | hr | p-p70S6K(T389) | -0.38786 | 1.90220 |
| WM-115 | 5 | hr | p-S6(S235/236) | 2.25700 | -1.13290 |
| WM-115 | 5 | hr | p-AMPK(T172) | -1.87560 | 2.34610 |
| WM-115 | 5 | hr | p-JNK(T183/Y185) | -1.09910 | 2.08810 |
| WM-115 | 5 | hr | Total c-Jun | 0.65055 | -0.20328 |
| WM-115 | 5 | hr | p-cJun(S63) | -1.24780 | 1.88260 |
| WM-115 | 5 | hr | p-P38(T180/Y182) | 0.37531 | 0.57042 |
| WM-115 | 5 | hr | p-HSP27(S82) | 0.13309 | 0.56909 |
| WM-115 | 5 | hr | p-NFKB(S536) | -0.31367 | 1.09260 |
| WM-115 | 5 | hr | Bim | -2.55830 | 2.48160 |
| WM-115 | 5 | hr | cPARP | -0.51240 | 0.73068 |
| WM-115 | 5 | hr | p-Histone H3(S10) | -2.85510 | 1.28190 |
| WM-115 | 5 | hr | p27 Kip1 | 0.01188 | 0.81311 |
| WM-115 | 10 | hr | p-p90RSK(S380) | 2.87510 | 0.00454 |
| WM-115 | 10 | hr | p-p90RSK(T573) | 0.00910 | 0.49154 |