PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 48 | hr | p-JNK(T183/Y185) | -1.10790 | -2.54890 |
| SKMEL28 | 48 | hr | Total c-Jun | -2.67440 | -1.19760 |
| SKMEL28 | 48 | hr | p-cJun(S63) | -3.20790 | -1.70140 |
| SKMEL28 | 48 | hr | p-P38(T180/Y182) | 1.06970 | 1.29130 |
| SKMEL28 | 48 | hr | p-HSP27(S82) | -1.32470 | -1.72500 |
| SKMEL28 | 48 | hr | p-NFKB(S536) | 2.64160 | -1.49920 |
| SKMEL28 | 48 | hr | Bim | -5.79870 | -1.44570 |
| SKMEL28 | 48 | hr | cPARP | -4.18310 | -2.59970 |
| SKMEL28 | 48 | hr | p-Histone H3(S10) | 6.72420 | 1.09740 |
| SKMEL28 | 48 | hr | p27 Kip1 | -6.78830 | -1.77840 |
| WM-115 | 1 | hr | p-p90RSK(S380) | 3.09170 | -0.14606 |
| WM-115 | 1 | hr | p-p90RSK(T573) | 1.07390 | 1.10720 |
| WM-115 | 1 | hr | p-AKT(T308) | 2.57760 | 1.68540 |
| WM-115 | 1 | hr | p-AKT(S473) | 0.91630 | 1.13510 |
| WM-115 | 1 | hr | p-mTOR(S2448) | 1.28310 | 1.22770 |
| WM-115 | 1 | hr | p-p70S6K(T421/S424) | 2.41270 | 0.28057 |
| WM-115 | 1 | hr | p-p70S6K(T389) | 2.66430 | 0.77981 |
| WM-115 | 1 | hr | p-S6(S235/236) | 0.24218 | -0.90656 |
| WM-115 | 1 | hr | p-AMPK(T172) | 1.38380 | 2.26990 |
| WM-115 | 1 | hr | p-JNK(T183/Y185) | 3.57020 | 0.46826 |
| WM-115 | 1 | hr | Total c-Jun | 2.55890 | 0.11735 |
| WM-115 | 1 | hr | p-cJun(S63) | 1.50590 | 1.57880 |
| WM-115 | 1 | hr | p-P38(T180/Y182) | 3.78060 | 0.04837 |
| WM-115 | 1 | hr | p-HSP27(S82) | -0.87975 | 0.52295 |
| WM-115 | 1 | hr | p-NFKB(S536) | 0.75815 | 1.36870 |