PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 24 | hr | p-AKT(S473) | -1.34760 | -0.68072 |
| SKMEL28 | 24 | hr | p-mTOR(S2448) | 4.80350 | -0.52596 |
| SKMEL28 | 24 | hr | p-p70S6K(T421/S424) | 5.32290 | -0.20564 |
| SKMEL28 | 24 | hr | p-p70S6K(T389) | 4.29420 | -0.05781 |
| SKMEL28 | 24 | hr | p-S6(S235/236) | 4.90240 | -0.59812 |
| SKMEL28 | 24 | hr | p-AMPK(T172) | -1.88150 | 0.27422 |
| SKMEL28 | 24 | hr | p-JNK(T183/Y185) | -1.87110 | -0.89274 |
| SKMEL28 | 24 | hr | Total c-Jun | -0.33607 | -0.36379 |
| SKMEL28 | 24 | hr | p-cJun(S63) | -1.54510 | -0.08040 |
| SKMEL28 | 24 | hr | p-P38(T180/Y182) | -4.18160 | -1.15700 |
| SKMEL28 | 24 | hr | p-HSP27(S82) | -0.64578 | 0.12498 |
| SKMEL28 | 24 | hr | p-NFKB(S536) | 4.04220 | 0.53719 |
| SKMEL28 | 24 | hr | Bim | -4.36260 | -0.19269 |
| SKMEL28 | 24 | hr | cPARP | -3.94500 | -1.07290 |
| SKMEL28 | 24 | hr | p-Histone H3(S10) | 7.27830 | 0.00342 |
| SKMEL28 | 24 | hr | p27 Kip1 | -4.65640 | -0.61131 |
| SKMEL28 | 48 | hr | p-p90RSK(S380) | 1.96040 | 2.56740 |
| SKMEL28 | 48 | hr | p-p90RSK(T573) | 2.29260 | 1.86660 |
| SKMEL28 | 48 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 48 | hr | p-AKT(S473) | -0.64653 | -1.65360 |
| SKMEL28 | 48 | hr | p-mTOR(S2448) | 2.04570 | -1.49260 |
| SKMEL28 | 48 | hr | p-p70S6K(T421/S424) | 2.56920 | -1.19050 |
| SKMEL28 | 48 | hr | p-p70S6K(T389) | 1.48190 | -0.75960 |
| SKMEL28 | 48 | hr | p-S6(S235/236) | 2.86060 | -0.48775 |
| SKMEL28 | 48 | hr | p-AMPK(T172) | -3.14310 | -1.14950 |