PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 1 | hr | p-p90RSK(S380) | 1.43730 | 0.55296 |
| MZ7-mel | 1 | hr | p-p90RSK(T573) | -0.20303 | -0.70107 |
| MZ7-mel | 1 | hr | p-AKT(T308) | 1.40230 | -0.59955 |
| MZ7-mel | 1 | hr | p-AKT(S473) | 2.49020 | 0.81500 |
| MZ7-mel | 1 | hr | p-mTOR(S2448) | 0.68743 | 0.53584 |
| MZ7-mel | 1 | hr | p-p70S6K(T421/S424) | 2.27080 | 1.32250 |
| MZ7-mel | 1 | hr | p-p70S6K(T389) | 1.65390 | -0.15880 |
| MZ7-mel | 1 | hr | p-S6(S235/236) | 1.08880 | 0.30016 |
| MZ7-mel | 1 | hr | p-AMPK(T172) | -0.56998 | -0.28141 |
| MZ7-mel | 1 | hr | p-JNK(T183/Y185) | 0.52310 | 0.92507 |
| MZ7-mel | 1 | hr | Total c-Jun | 2.03650 | 1.01370 |
| MZ7-mel | 1 | hr | p-cJun(S63) | 0.75632 | 0.83934 |
| MZ7-mel | 1 | hr | p-P38(T180/Y182) | 2.72180 | 0.90833 |
| MZ7-mel | 1 | hr | p-HSP27(S82) | 0.59831 | 0.16347 |
| MZ7-mel | 1 | hr | p-NFKB(S536) | 0.50188 | 0.46724 |
| MZ7-mel | 1 | hr | Bim | -0.31133 | -0.07806 |
| MZ7-mel | 1 | hr | cPARP | 0.11834 | -0.22580 |
| MZ7-mel | 1 | hr | p-Histone H3(S10) | -0.46973 | -0.37190 |
| MZ7-mel | 1 | hr | p27 Kip1 | 0.40996 | 0.26787 |
| MZ7-mel | 5 | hr | p-p90RSK(S380) | -1.65010 | -2.49340 |
| MZ7-mel | 5 | hr | p-p90RSK(T573) | -2.90740 | -2.16400 |
| MZ7-mel | 5 | hr | p-AKT(T308) | -1.79470 | -1.79090 |
| MZ7-mel | 5 | hr | p-AKT(S473) | -2.74790 | -2.30700 |
| MZ7-mel | 5 | hr | p-mTOR(S2448) | -2.49350 | -2.33630 |
| MZ7-mel | 5 | hr | p-p70S6K(T421/S424) | -1.74550 | -2.24660 |