PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 24 | hr | p-HSP27(S82) | -7.08160 | 0.14567 |
| MMAC-SF | 24 | hr | p-NFKB(S536) | -3.36310 | 0.60518 |
| MMAC-SF | 24 | hr | Bim | -7.79580 | -1.41500 |
| MMAC-SF | 24 | hr | cPARP | -7.08530 | -1.69720 |
| MMAC-SF | 24 | hr | p-Histone H3(S10) | 5.03680 | 2.64560 |
| MMAC-SF | 24 | hr | p27 Kip1 | -8.74820 | -2.17230 |
| MMAC-SF | 48 | hr | p-p90RSK(S380) | 5.05320 | -2.13280 |
| MMAC-SF | 48 | hr | p-p90RSK(T573) | 6.45900 | -1.81680 |
| MMAC-SF | 48 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 48 | hr | p-AKT(S473) | 1.56980 | -2.65300 |
| MMAC-SF | 48 | hr | p-mTOR(S2448) | 4.17840 | -0.83641 |
| MMAC-SF | 48 | hr | p-p70S6K(T421/S424) | 5.45550 | -1.80060 |
| MMAC-SF | 48 | hr | p-p70S6K(T389) | 4.85590 | -0.01976 |
| MMAC-SF | 48 | hr | p-S6(S235/236) | 6.95830 | 1.91470 |
| MMAC-SF | 48 | hr | p-AMPK(T172) | 4.99830 | -0.86464 |
| MMAC-SF | 48 | hr | p-JNK(T183/Y185) | 3.36320 | -1.18560 |
| MMAC-SF | 48 | hr | Total c-Jun | 5.17630 | -0.75797 |
| MMAC-SF | 48 | hr | p-cJun(S63) | 2.48970 | -1.84240 |
| MMAC-SF | 48 | hr | p-P38(T180/Y182) | 2.31310 | 0.09979 |
| MMAC-SF | 48 | hr | p-HSP27(S82) | 0.92369 | -1.96430 |
| MMAC-SF | 48 | hr | p-NFKB(S536) | 5.56720 | -0.52969 |
| MMAC-SF | 48 | hr | Bim | 0.59534 | -2.65750 |
| MMAC-SF | 48 | hr | cPARP | -0.18759 | -2.64540 |
| MMAC-SF | 48 | hr | p-Histone H3(S10) | 6.49630 | 1.48510 |
| MMAC-SF | 48 | hr | p27 Kip1 | 0.10900 | -2.01590 |