PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 1 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 1 | hr | p-p90RSK(T573) | -0.08305 | 1.01290 |
| C32 | 1 | hr | p-AKT(T308) | -0.02290 | -1.29110 |
| C32 | 1 | hr | p-AKT(S473) | -1.28370 | -2.03900 |
| C32 | 1 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 1 | hr | p-p70S6K(T421/S424) | 1.30180 | -0.26785 |
| C32 | 1 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 1 | hr | p-S6(S235/236) | 1.61560 | -0.33704 |
| C32 | 1 | hr | p-AMPK(T172) | -0.72271 | -0.59999 |
| C32 | 1 | hr | p-JNK(T183/Y185) | 0.71127 | -1.03380 |
| C32 | 1 | hr | Total c-Jun | 1.22180 | 0.50708 |
| C32 | 1 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 1 | hr | p-P38(T180/Y182) | 1.92970 | 0.38577 |
| C32 | 1 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 1 | hr | p-NFKB(S536) | 1.42320 | -0.02375 |
| C32 | 1 | hr | Bim | -0.20113 | -0.07848 |
| C32 | 1 | hr | cPARP | 0.92314 | -0.40636 |
| C32 | 1 | hr | p-Histone H3(S10) | -0.57917 | 0.30645 |
| C32 | 1 | hr | p27 Kip1 | 0.24919 | 0.42253 |
| C32 | 5 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 5 | hr | p-p90RSK(T573) | -1.64240 | 1.46240 |
| C32 | 5 | hr | p-AKT(T308) | -1.74290 | -0.33436 |
| C32 | 5 | hr | p-AKT(S473) | -3.46650 | 0.08197 |
| C32 | 5 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 5 | hr | p-p70S6K(T421/S424) | 1.37550 | -0.30846 |