PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 1 | hr | Total c-Jun | 1.55650 | 0.49971 |
| K2 | 1 | hr | p-cJun(S63) | 0.80995 | 0.17331 |
| K2 | 1 | hr | p-P38(T180/Y182) | 1.92390 | 0.34877 |
| K2 | 1 | hr | p-HSP27(S82) | 0.85558 | 0.62302 |
| K2 | 1 | hr | p-NFKB(S536) | 0.64252 | -0.10407 |
| K2 | 1 | hr | Bim | 0.48026 | 0.28118 |
| K2 | 1 | hr | cPARP | 0.47576 | 0.62894 |
| K2 | 1 | hr | p-Histone H3(S10) | 0.01678 | 0.17476 |
| K2 | 1 | hr | p27 Kip1 | 0.40692 | 0.01184 |
| K2 | 5 | hr | p-p90RSK(S380) | -0.93630 | 1.83870 |
| K2 | 5 | hr | p-p90RSK(T573) | -0.98591 | 1.75240 |
| K2 | 5 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 5 | hr | p-AKT(S473) | -2.06920 | 1.25820 |
| K2 | 5 | hr | p-mTOR(S2448) | -2.36860 | 1.31360 |
| K2 | 5 | hr | p-p70S6K(T421/S424) | -1.62940 | 0.50825 |
| K2 | 5 | hr | p-p70S6K(T389) | 1.27020 | 1.04840 |
| K2 | 5 | hr | p-S6(S235/236) | 1.54360 | 0.65013 |
| K2 | 5 | hr | p-AMPK(T172) | -2.77740 | 2.42370 |
| K2 | 5 | hr | p-JNK(T183/Y185) | -1.94970 | 1.40120 |
| K2 | 5 | hr | Total c-Jun | 1.38750 | 1.03820 |
| K2 | 5 | hr | p-cJun(S63) | 0.38180 | 0.65797 |
| K2 | 5 | hr | p-P38(T180/Y182) | -0.97295 | 0.77814 |
| K2 | 5 | hr | p-HSP27(S82) | -1.21420 | 0.86781 |
| K2 | 5 | hr | p-NFKB(S536) | -2.75480 | 0.72246 |
| K2 | 5 | hr | Bim | -2.41500 | 0.90851 |