PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 48 | hr | p-mTOR(S2448) | 6.06640 | -2.80510 |
| COLO 858 | 48 | hr | p-p70S6K(T421/S424) | 6.89160 | -1.46800 |
| COLO 858 | 48 | hr | p-p70S6K(T389) | -0.17397 | 0.03130 |
| COLO 858 | 48 | hr | p-S6(S235/236) | 5.64440 | 0.38080 |
| COLO 858 | 48 | hr | p-AMPK(T172) | 0.70992 | -0.06853 |
| COLO 858 | 48 | hr | p-JNK(T183/Y185) | 0.13623 | -1.73760 |
| COLO 858 | 48 | hr | Total c-Jun | -2.62820 | -1.60880 |
| COLO 858 | 48 | hr | p-cJun(S63) | -3.64000 | -1.28270 |
| COLO 858 | 48 | hr | p-P38(T180/Y182) | 1.91710 | -1.01170 |
| COLO 858 | 48 | hr | p-HSP27(S82) | 1.59200 | -1.55600 |
| COLO 858 | 48 | hr | p-NFKB(S536) | 2.50790 | 1.04350 |
| COLO 858 | 48 | hr | Bim | 0.82671 | -0.20180 |
| COLO 858 | 48 | hr | cPARP | -3.39660 | 1.67800 |
| COLO 858 | 48 | hr | p-Histone H3(S10) | 8.38510 | 1.68050 |
| COLO 858 | 48 | hr | p27 Kip1 | -3.20430 | -0.74402 |
| K2 | 1 | hr | p-p90RSK(S380) | 2.07590 | 1.67090 |
| K2 | 1 | hr | p-p90RSK(T573) | 1.90520 | 1.77580 |
| K2 | 1 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 1 | hr | p-AKT(S473) | -0.35125 | -0.10209 |
| K2 | 1 | hr | p-mTOR(S2448) | 0.60137 | 0.38921 |
| K2 | 1 | hr | p-p70S6K(T421/S424) | 2.09350 | 0.12327 |
| K2 | 1 | hr | p-p70S6K(T389) | 1.24120 | 0.19064 |
| K2 | 1 | hr | p-S6(S235/236) | 1.12360 | 0.46806 |
| K2 | 1 | hr | p-AMPK(T172) | 0.20143 | 0.30636 |
| K2 | 1 | hr | p-JNK(T183/Y185) | 1.76080 | 1.23340 |