PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 10 | hr | p-Histone H3(S10) | 0.93850 | 0.06628 |
| COLO 858 | 10 | hr | p27 Kip1 | -0.58925 | -0.54081 |
| COLO 858 | 24 | hr | p-p90RSK(S380) | -1.20110 | 0.32008 |
| COLO 858 | 24 | hr | p-p90RSK(T573) | -1.36010 | -0.25342 |
| COLO 858 | 24 | hr | p-AKT(T308) | -7.18280 | 0.63035 |
| COLO 858 | 24 | hr | p-AKT(S473) | -4.98200 | 0.56557 |
| COLO 858 | 24 | hr | p-mTOR(S2448) | -1.59290 | -0.36502 |
| COLO 858 | 24 | hr | p-p70S6K(T421/S424) | 0.05893 | 0.14932 |
| COLO 858 | 24 | hr | p-p70S6K(T389) | 6.39000 | 1.39710 |
| COLO 858 | 24 | hr | p-S6(S235/236) | 5.55500 | 0.61054 |
| COLO 858 | 24 | hr | p-AMPK(T172) | -0.86349 | 0.43362 |
| COLO 858 | 24 | hr | p-JNK(T183/Y185) | -6.66110 | 0.32344 |
| COLO 858 | 24 | hr | Total c-Jun | -3.03300 | -1.13490 |
| COLO 858 | 24 | hr | p-cJun(S63) | -3.58480 | -1.29950 |
| COLO 858 | 24 | hr | p-P38(T180/Y182) | -0.94057 | -1.14380 |
| COLO 858 | 24 | hr | p-HSP27(S82) | -1.41810 | -2.15680 |
| COLO 858 | 24 | hr | p-NFKB(S536) | 2.35730 | 0.92111 |
| COLO 858 | 24 | hr | Bim | -7.49980 | -0.74041 |
| COLO 858 | 24 | hr | cPARP | -4.05920 | 0.97754 |
| COLO 858 | 24 | hr | p-Histone H3(S10) | 2.00440 | 0.16239 |
| COLO 858 | 24 | hr | p27 Kip1 | -6.87460 | -0.98048 |
| COLO 858 | 48 | hr | p-p90RSK(S380) | 4.48040 | -2.25410 |
| COLO 858 | 48 | hr | p-p90RSK(T573) | 4.71400 | -2.15680 |
| COLO 858 | 48 | hr | p-AKT(T308) | 0.95508 | -0.37715 |
| COLO 858 | 48 | hr | p-AKT(S473) | 0.84621 | -0.01638 |