PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 5 | hr | p-cJun(S63) | -1.78570 | -0.42398 |
| COLO 858 | 5 | hr | p-P38(T180/Y182) | -0.49690 | -1.21450 |
| COLO 858 | 5 | hr | p-HSP27(S82) | 0.20234 | -2.85020 |
| COLO 858 | 5 | hr | p-NFKB(S536) | -1.07140 | 1.00780 |
| COLO 858 | 5 | hr | Bim | -3.24470 | -0.37663 |
| COLO 858 | 5 | hr | cPARP | -3.73520 | 1.33550 |
| COLO 858 | 5 | hr | p-Histone H3(S10) | -2.18630 | 0.44189 |
| COLO 858 | 5 | hr | p27 Kip1 | -1.98820 | -0.61425 |
| COLO 858 | 10 | hr | p-p90RSK(S380) | 3.81740 | 0.27681 |
| COLO 858 | 10 | hr | p-p90RSK(T573) | 1.13520 | -0.84447 |
| COLO 858 | 10 | hr | p-AKT(T308) | 1.09790 | -0.48443 |
| COLO 858 | 10 | hr | p-AKT(S473) | 0.28039 | 0.16425 |
| COLO 858 | 10 | hr | p-mTOR(S2448) | 1.80060 | -0.25214 |
| COLO 858 | 10 | hr | p-p70S6K(T421/S424) | 2.90240 | -0.31822 |
| COLO 858 | 10 | hr | p-p70S6K(T389) | 5.16350 | 0.64808 |
| COLO 858 | 10 | hr | p-S6(S235/236) | 5.35310 | 0.47738 |
| COLO 858 | 10 | hr | p-AMPK(T172) | 2.27990 | -0.13635 |
| COLO 858 | 10 | hr | p-JNK(T183/Y185) | 0.96668 | 0.24860 |
| COLO 858 | 10 | hr | Total c-Jun | 5.64660 | -0.09352 |
| COLO 858 | 10 | hr | p-cJun(S63) | 2.46090 | -0.50409 |
| COLO 858 | 10 | hr | p-P38(T180/Y182) | 3.75790 | -0.93847 |
| COLO 858 | 10 | hr | p-HSP27(S82) | 0.42086 | -2.47090 |
| COLO 858 | 10 | hr | p-NFKB(S536) | 6.86470 | -0.02375 |
| COLO 858 | 10 | hr | Bim | -0.35083 | -0.53756 |
| COLO 858 | 10 | hr | cPARP | 3.07970 | 0.43763 |