PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 5 | hr | p-p90RSK(T573) | -2.46950 | 0.17693 |
| MMAC-SF | 5 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 5 | hr | p-AKT(S473) | -4.49460 | -0.92136 |
| MMAC-SF | 5 | hr | p-mTOR(S2448) | -3.79800 | 0.13167 |
| MMAC-SF | 5 | hr | p-p70S6K(T421/S424) | -2.29380 | -0.82898 |
| MMAC-SF | 5 | hr | p-p70S6K(T389) | -3.29340 | 1.13080 |
| MMAC-SF | 5 | hr | p-S6(S235/236) | 1.25680 | 0.52988 |
| MMAC-SF | 5 | hr | p-AMPK(T172) | -3.46410 | -0.69623 |
| MMAC-SF | 5 | hr | p-JNK(T183/Y185) | -3.77410 | 0.55959 |
| MMAC-SF | 5 | hr | Total c-Jun | 1.39460 | 0.87369 |
| MMAC-SF | 5 | hr | p-cJun(S63) | -3.71130 | -0.34678 |
| MMAC-SF | 5 | hr | p-P38(T180/Y182) | -1.62720 | 1.53910 |
| MMAC-SF | 5 | hr | p-HSP27(S82) | -4.29980 | -0.16738 |
| MMAC-SF | 5 | hr | p-NFKB(S536) | -2.32380 | 0.11142 |
| MMAC-SF | 5 | hr | Bim | -3.99810 | -0.77246 |
| MMAC-SF | 5 | hr | cPARP | -2.80630 | -1.06660 |
| MMAC-SF | 5 | hr | p-Histone H3(S10) | -1.20870 | -0.19727 |
| MMAC-SF | 5 | hr | p27 Kip1 | -2.59720 | -0.74107 |
| MMAC-SF | 10 | hr | p-p90RSK(S380) | 3.90590 | -0.84569 |
| MMAC-SF | 10 | hr | p-p90RSK(T573) | 1.85100 | -1.01860 |
| MMAC-SF | 10 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 10 | hr | p-AKT(S473) | 1.59060 | -1.34520 |
| MMAC-SF | 10 | hr | p-mTOR(S2448) | 3.62620 | -0.44509 |
| MMAC-SF | 10 | hr | p-p70S6K(T421/S424) | 3.80410 | -1.53510 |
| MMAC-SF | 10 | hr | p-p70S6K(T389) | 3.51470 | 0.42585 |