PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 48 | hr | p-NFKB(S536) | 0.47359 | 0.11448 |
| LOXIMVI | 48 | hr | Bim | 0.06177 | -0.87670 |
| LOXIMVI | 48 | hr | cPARP | 0.20754 | -0.07013 |
| LOXIMVI | 48 | hr | p-Histone H3(S10) | 3.78040 | 0.53335 |
| LOXIMVI | 48 | hr | p27 Kip1 | -0.19682 | -1.12940 |
| MMAC-SF | 1 | hr | p-p90RSK(S380) | 4.83130 | -0.59006 |
| MMAC-SF | 1 | hr | p-p90RSK(T573) | 2.97050 | -0.45467 |
| MMAC-SF | 1 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 1 | hr | p-AKT(S473) | 1.87970 | -1.20210 |
| MMAC-SF | 1 | hr | p-mTOR(S2448) | 3.74760 | -0.99595 |
| MMAC-SF | 1 | hr | p-p70S6K(T421/S424) | 4.36610 | -1.81920 |
| MMAC-SF | 1 | hr | p-p70S6K(T389) | 4.22930 | -0.20444 |
| MMAC-SF | 1 | hr | p-S6(S235/236) | 1.60860 | 0.08240 |
| MMAC-SF | 1 | hr | p-AMPK(T172) | 3.72670 | -1.07660 |
| MMAC-SF | 1 | hr | p-JNK(T183/Y185) | 3.90110 | -0.03276 |
| MMAC-SF | 1 | hr | Total c-Jun | 4.07580 | -0.37925 |
| MMAC-SF | 1 | hr | p-cJun(S63) | 3.04950 | -0.26049 |
| MMAC-SF | 1 | hr | p-P38(T180/Y182) | 4.92160 | 0.75900 |
| MMAC-SF | 1 | hr | p-HSP27(S82) | 3.11130 | 0.00372 |
| MMAC-SF | 1 | hr | p-NFKB(S536) | 3.01170 | -1.59150 |
| MMAC-SF | 1 | hr | Bim | 2.33420 | -1.14560 |
| MMAC-SF | 1 | hr | cPARP | 2.73170 | -0.63696 |
| MMAC-SF | 1 | hr | p-Histone H3(S10) | 1.25220 | -0.29564 |
| MMAC-SF | 1 | hr | p27 Kip1 | 2.65150 | -1.45790 |
| MMAC-SF | 5 | hr | p-p90RSK(S380) | -2.28380 | 0.21402 |