PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 24 | hr | p-AMPK(T172) | -0.09058 | 1.49040 |
| LOXIMVI | 24 | hr | p-JNK(T183/Y185) | 1.31540 | 1.85360 |
| LOXIMVI | 24 | hr | Total c-Jun | 1.82100 | -0.07087 |
| LOXIMVI | 24 | hr | p-cJun(S63) | 0.29077 | -0.46001 |
| LOXIMVI | 24 | hr | p-P38(T180/Y182) | 0.96614 | 1.54320 |
| LOXIMVI | 24 | hr | p-HSP27(S82) | 1.26050 | 0.51399 |
| LOXIMVI | 24 | hr | p-NFKB(S536) | 1.19050 | 1.61930 |
| LOXIMVI | 24 | hr | Bim | 0.58901 | 2.15340 |
| LOXIMVI | 24 | hr | cPARP | 0.65458 | 1.89690 |
| LOXIMVI | 24 | hr | p-Histone H3(S10) | 4.01230 | 1.20020 |
| LOXIMVI | 24 | hr | p27 Kip1 | 0.20392 | -0.39136 |
| LOXIMVI | 48 | hr | p-p90RSK(S380) | 1.54510 | -0.06033 |
| LOXIMVI | 48 | hr | p-p90RSK(T573) | 0.21866 | -0.14161 |
| LOXIMVI | 48 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 48 | hr | p-AKT(S473) | 1.27240 | -1.37000 |
| LOXIMVI | 48 | hr | p-mTOR(S2448) | 1.13780 | -0.86291 |
| LOXIMVI | 48 | hr | p-p70S6K(T421/S424) | 1.76540 | -1.82010 |
| LOXIMVI | 48 | hr | p-p70S6K(T389) | 2.27660 | -1.25570 |
| LOXIMVI | 48 | hr | p-S6(S235/236) | -0.48195 | 0.73247 |
| LOXIMVI | 48 | hr | p-AMPK(T172) | -0.41897 | -1.56950 |
| LOXIMVI | 48 | hr | p-JNK(T183/Y185) | 0.78232 | -0.97404 |
| LOXIMVI | 48 | hr | Total c-Jun | 0.87113 | -0.68673 |
| LOXIMVI | 48 | hr | p-cJun(S63) | -0.69371 | -1.28270 |
| LOXIMVI | 48 | hr | p-P38(T180/Y182) | 0.85795 | -0.79429 |
| LOXIMVI | 48 | hr | p-HSP27(S82) | 0.62521 | -1.48830 |