PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 10 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 10 | hr | p-AKT(S473) | 2.28950 | -0.33653 |
| LOXIMVI | 10 | hr | p-mTOR(S2448) | 3.87860 | -1.70930 |
| LOXIMVI | 10 | hr | p-p70S6K(T421/S424) | 3.73410 | -1.58830 |
| LOXIMVI | 10 | hr | p-p70S6K(T389) | 3.52180 | -1.68400 |
| LOXIMVI | 10 | hr | p-S6(S235/236) | 1.39480 | -0.56202 |
| LOXIMVI | 10 | hr | p-AMPK(T172) | 2.46440 | -1.24900 |
| LOXIMVI | 10 | hr | p-JNK(T183/Y185) | 3.04990 | -1.07420 |
| LOXIMVI | 10 | hr | Total c-Jun | 2.43270 | -1.14050 |
| LOXIMVI | 10 | hr | p-cJun(S63) | 0.95479 | -2.04460 |
| LOXIMVI | 10 | hr | p-P38(T180/Y182) | 2.89090 | -1.46940 |
| LOXIMVI | 10 | hr | p-HSP27(S82) | 2.88220 | -1.67300 |
| LOXIMVI | 10 | hr | p-NFKB(S536) | 4.19930 | -1.28460 |
| LOXIMVI | 10 | hr | Bim | 3.08970 | -0.95133 |
| LOXIMVI | 10 | hr | cPARP | 2.39850 | -0.62375 |
| LOXIMVI | 10 | hr | p-Histone H3(S10) | 1.51280 | -0.26960 |
| LOXIMVI | 10 | hr | p27 Kip1 | 1.52140 | -0.99880 |
| LOXIMVI | 24 | hr | p-p90RSK(S380) | 2.60120 | 1.27040 |
| LOXIMVI | 24 | hr | p-p90RSK(T573) | 1.18400 | 0.50146 |
| LOXIMVI | 24 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 24 | hr | p-AKT(S473) | -0.16581 | 1.58000 |
| LOXIMVI | 24 | hr | p-mTOR(S2448) | 1.60990 | 1.25260 |
| LOXIMVI | 24 | hr | p-p70S6K(T421/S424) | 1.32970 | 1.63210 |
| LOXIMVI | 24 | hr | p-p70S6K(T389) | 2.46950 | 1.78020 |
| LOXIMVI | 24 | hr | p-S6(S235/236) | 1.41140 | -0.20420 |