PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 24 | hr | p27 Kip1 | -6.36380 | 0.34918 |
| C32 | 48 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 48 | hr | p-p90RSK(T573) | -1.30300 | -1.19070 |
| C32 | 48 | hr | p-AKT(T308) | -7.52260 | 0.08243 |
| C32 | 48 | hr | p-AKT(S473) | -0.36254 | 2.71710 |
| C32 | 48 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 48 | hr | p-p70S6K(T421/S424) | 4.91750 | -0.36024 |
| C32 | 48 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 48 | hr | p-S6(S235/236) | 3.49980 | 0.12618 |
| C32 | 48 | hr | p-AMPK(T172) | -8.05440 | -1.13410 |
| C32 | 48 | hr | p-JNK(T183/Y185) | -1.84920 | 1.46490 |
| C32 | 48 | hr | Total c-Jun | 0.80821 | 2.29570 |
| C32 | 48 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 48 | hr | p-P38(T180/Y182) | -4.73310 | 1.76430 |
| C32 | 48 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 48 | hr | p-NFKB(S536) | 0.96642 | 3.13050 |
| C32 | 48 | hr | Bim | -8.07140 | 0.97247 |
| C32 | 48 | hr | cPARP | -9.15590 | -2.27710 |
| C32 | 48 | hr | p-Histone H3(S10) | 6.96610 | -0.16175 |
| C32 | 48 | hr | p27 Kip1 | -7.76980 | -0.16574 |
| COLO 858 | 1 | hr | p-p90RSK(S380) | 1.98500 | 0.80000 |
| COLO 858 | 1 | hr | p-p90RSK(T573) | 1.50550 | -0.61149 |
| COLO 858 | 1 | hr | p-AKT(T308) | 2.34140 | -0.13343 |
| COLO 858 | 1 | hr | p-AKT(S473) | 1.08110 | 0.36472 |
| COLO 858 | 1 | hr | p-mTOR(S2448) | 1.79660 | -0.12294 |