PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 1 | hr | p-p70S6K(T421/S424) | 2.91540 | -0.34037 |
| COLO 858 | 1 | hr | p-p70S6K(T389) | 0.22187 | -0.73515 |
| COLO 858 | 1 | hr | p-S6(S235/236) | 1.58900 | -0.01293 |
| COLO 858 | 1 | hr | p-AMPK(T172) | 0.31062 | -0.25957 |
| COLO 858 | 1 | hr | p-JNK(T183/Y185) | 1.51560 | -0.37941 |
| COLO 858 | 1 | hr | Total c-Jun | 4.04310 | -0.69013 |
| COLO 858 | 1 | hr | p-cJun(S63) | 2.42140 | -0.81656 |
| COLO 858 | 1 | hr | p-P38(T180/Y182) | 4.72910 | -1.55320 |
| COLO 858 | 1 | hr | p-HSP27(S82) | 0.93656 | -1.45690 |
| COLO 858 | 1 | hr | p-NFKB(S536) | 2.07200 | -0.69852 |
| COLO 858 | 1 | hr | Bim | 2.45530 | -0.58283 |
| COLO 858 | 1 | hr | cPARP | 2.11210 | 0.59193 |
| COLO 858 | 1 | hr | p-Histone H3(S10) | 0.73291 | 0.12099 |
| COLO 858 | 1 | hr | p27 Kip1 | 0.87846 | -0.42137 |
| COLO 858 | 5 | hr | p-p90RSK(S380) | -2.06700 | 0.34798 |
| COLO 858 | 5 | hr | p-p90RSK(T573) | -3.79830 | -1.03930 |
| COLO 858 | 5 | hr | p-AKT(T308) | -4.95650 | -0.22183 |
| COLO 858 | 5 | hr | p-AKT(S473) | -5.09380 | 0.09043 |
| COLO 858 | 5 | hr | p-mTOR(S2448) | -3.55730 | -0.50803 |
| COLO 858 | 5 | hr | p-p70S6K(T421/S424) | -1.91340 | -0.40637 |
| COLO 858 | 5 | hr | p-p70S6K(T389) | 2.78470 | 0.13315 |
| COLO 858 | 5 | hr | p-S6(S235/236) | 1.78800 | 0.58646 |
| COLO 858 | 5 | hr | p-AMPK(T172) | -1.17610 | -0.10252 |
| COLO 858 | 5 | hr | p-JNK(T183/Y185) | -3.92540 | -0.29876 |
| COLO 858 | 5 | hr | Total c-Jun | -0.23499 | -0.70922 |