PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 1 | hr | Bim | 3.58210 | -0.86495 |
| LOXIMVI | 1 | hr | cPARP | 2.61590 | -0.88816 |
| LOXIMVI | 1 | hr | p-Histone H3(S10) | 0.86121 | 0.20230 |
| LOXIMVI | 1 | hr | p27 Kip1 | 2.47680 | -1.84740 |
| LOXIMVI | 5 | hr | p-p90RSK(S380) | 1.59630 | 1.70520 |
| LOXIMVI | 5 | hr | p-p90RSK(T573) | 1.04290 | 0.60809 |
| LOXIMVI | 5 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 5 | hr | p-AKT(S473) | 0.28859 | 2.00260 |
| LOXIMVI | 5 | hr | p-mTOR(S2448) | 1.28890 | 1.52170 |
| LOXIMVI | 5 | hr | p-p70S6K(T421/S424) | 1.04070 | 1.88280 |
| LOXIMVI | 5 | hr | p-p70S6K(T389) | 1.27580 | 1.82640 |
| LOXIMVI | 5 | hr | p-S6(S235/236) | 0.67326 | -0.09839 |
| LOXIMVI | 5 | hr | p-AMPK(T172) | 0.55970 | 1.64360 |
| LOXIMVI | 5 | hr | p-JNK(T183/Y185) | 1.14550 | 1.35070 |
| LOXIMVI | 5 | hr | Total c-Jun | 1.35000 | 0.37604 |
| LOXIMVI | 5 | hr | p-cJun(S63) | -0.58397 | -0.27823 |
| LOXIMVI | 5 | hr | p-P38(T180/Y182) | 0.45082 | 1.71860 |
| LOXIMVI | 5 | hr | p-HSP27(S82) | 1.27850 | 0.79376 |
| LOXIMVI | 5 | hr | p-NFKB(S536) | 0.83022 | 2.42060 |
| LOXIMVI | 5 | hr | Bim | 1.11280 | 1.97810 |
| LOXIMVI | 5 | hr | cPARP | 1.00740 | 1.93750 |
| LOXIMVI | 5 | hr | p-Histone H3(S10) | 0.31803 | 1.14240 |
| LOXIMVI | 5 | hr | p27 Kip1 | 1.31320 | 0.16415 |
| LOXIMVI | 10 | hr | p-p90RSK(S380) | 3.14900 | -1.21240 |
| LOXIMVI | 10 | hr | p-p90RSK(T573) | 2.52280 | -0.49010 |