PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 5 | hr | cPARP | -1.90670 | 0.66820 |
| K2 | 5 | hr | p-Histone H3(S10) | -1.62060 | 0.18084 |
| K2 | 5 | hr | p27 Kip1 | -1.10480 | 0.13724 |
| K2 | 10 | hr | p-p90RSK(S380) | 2.61170 | 2.74580 |
| K2 | 10 | hr | p-p90RSK(T573) | 2.00360 | 2.20520 |
| K2 | 10 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 10 | hr | p-AKT(S473) | -0.08196 | 1.76760 |
| K2 | 10 | hr | p-mTOR(S2448) | 2.33150 | 2.84770 |
| K2 | 10 | hr | p-p70S6K(T421/S424) | 4.38530 | 1.84600 |
| K2 | 10 | hr | p-p70S6K(T389) | 4.54550 | 1.40200 |
| K2 | 10 | hr | p-S6(S235/236) | 5.63510 | 1.48240 |
| K2 | 10 | hr | p-AMPK(T172) | 2.38410 | 1.74620 |
| K2 | 10 | hr | p-JNK(T183/Y185) | 2.24250 | 2.52530 |
| K2 | 10 | hr | Total c-Jun | 4.02810 | 1.22920 |
| K2 | 10 | hr | p-cJun(S63) | 3.32430 | 1.20970 |
| K2 | 10 | hr | p-P38(T180/Y182) | 1.84190 | 1.37690 |
| K2 | 10 | hr | p-HSP27(S82) | 1.16630 | 1.52520 |
| K2 | 10 | hr | p-NFKB(S536) | 1.56720 | 1.28090 |
| K2 | 10 | hr | Bim | -0.56647 | 0.76614 |
| K2 | 10 | hr | cPARP | 0.60038 | 1.63880 |
| K2 | 10 | hr | p-Histone H3(S10) | -0.67023 | 0.38668 |
| K2 | 10 | hr | p27 Kip1 | -1.67340 | 0.10721 |
| K2 | 24 | hr | p-p90RSK(S380) | -5.12670 | 1.29540 |
| K2 | 24 | hr | p-p90RSK(T573) | -3.21670 | 2.06770 |
| K2 | 24 | hr | p-AKT(T308) | NaN | NaN |