PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 10 | hr | p-P38(T180/Y182) | 1.96790 | -0.07659 |
| MZ7-mel | 10 | hr | p-HSP27(S82) | 1.04880 | -0.32303 |
| MZ7-mel | 10 | hr | p-NFKB(S536) | 3.02840 | 0.23337 |
| MZ7-mel | 10 | hr | Bim | -0.85164 | -0.33551 |
| MZ7-mel | 10 | hr | cPARP | -0.50249 | -0.41077 |
| MZ7-mel | 10 | hr | p-Histone H3(S10) | -0.87656 | -0.09487 |
| MZ7-mel | 10 | hr | p27 Kip1 | -1.21760 | 0.21346 |
| MZ7-mel | 24 | hr | p-p90RSK(S380) | -1.18970 | -0.42896 |
| MZ7-mel | 24 | hr | p-p90RSK(T573) | 2.29180 | 0.72917 |
| MZ7-mel | 24 | hr | p-AKT(T308) | -2.19800 | -0.72599 |
| MZ7-mel | 24 | hr | p-AKT(S473) | -1.78390 | -0.27270 |
| MZ7-mel | 24 | hr | p-mTOR(S2448) | -2.55160 | -0.50719 |
| MZ7-mel | 24 | hr | p-p70S6K(T421/S424) | 1.62440 | -0.14348 |
| MZ7-mel | 24 | hr | p-p70S6K(T389) | -0.38268 | -0.60875 |
| MZ7-mel | 24 | hr | p-S6(S235/236) | 5.76980 | -0.10641 |
| MZ7-mel | 24 | hr | p-AMPK(T172) | -2.33600 | -0.27173 |
| MZ7-mel | 24 | hr | p-JNK(T183/Y185) | -2.15640 | -0.32181 |
| MZ7-mel | 24 | hr | Total c-Jun | 0.79668 | 0.79393 |
| MZ7-mel | 24 | hr | p-cJun(S63) | -3.23580 | 0.01616 |
| MZ7-mel | 24 | hr | p-P38(T180/Y182) | 1.22550 | 0.57535 |
| MZ7-mel | 24 | hr | p-HSP27(S82) | -3.20470 | -0.79218 |
| MZ7-mel | 24 | hr | p-NFKB(S536) | -1.56620 | -0.73620 |
| MZ7-mel | 24 | hr | Bim | -6.01010 | -0.84793 |
| MZ7-mel | 24 | hr | cPARP | -6.00290 | 0.23558 |
| MZ7-mel | 24 | hr | p-Histone H3(S10) | 2.38120 | 0.75651 |