PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 24 | hr | p-AMPK(T172) | -1.74470 | 2.79070 |
| WM-115 | 24 | hr | p-JNK(T183/Y185) | -0.79316 | 1.53200 |
| WM-115 | 24 | hr | Total c-Jun | -0.95557 | 1.08570 |
| WM-115 | 24 | hr | p-cJun(S63) | -1.48400 | 2.83390 |
| WM-115 | 24 | hr | p-P38(T180/Y182) | -0.92772 | 0.90729 |
| WM-115 | 24 | hr | p-HSP27(S82) | -0.22363 | 1.24180 |
| WM-115 | 24 | hr | p-NFKB(S536) | -1.29040 | 1.92940 |
| WM-115 | 24 | hr | Bim | -1.72050 | 2.57480 |
| WM-115 | 24 | hr | cPARP | 0.63083 | 0.80570 |
| WM-115 | 24 | hr | p-Histone H3(S10) | -0.50661 | 0.96938 |
| WM-115 | 24 | hr | p27 Kip1 | -0.96408 | 1.78910 |
| WM-115 | 48 | hr | p-p90RSK(S380) | 3.79590 | 2.02110 |
| WM-115 | 48 | hr | p-p90RSK(T573) | 3.36150 | 2.12990 |
| WM-115 | 48 | hr | p-AKT(T308) | -1.62190 | 1.43010 |
| WM-115 | 48 | hr | p-AKT(S473) | -0.68218 | 1.56430 |
| WM-115 | 48 | hr | p-mTOR(S2448) | 1.06400 | 3.13860 |
| WM-115 | 48 | hr | p-p70S6K(T421/S424) | 4.24490 | 1.86310 |
| WM-115 | 48 | hr | p-p70S6K(T389) | 2.06620 | 2.99540 |
| WM-115 | 48 | hr | p-S6(S235/236) | 6.35250 | -2.04960 |
| WM-115 | 48 | hr | p-AMPK(T172) | -2.78430 | 3.13500 |
| WM-115 | 48 | hr | p-JNK(T183/Y185) | 0.78954 | 2.23400 |
| WM-115 | 48 | hr | Total c-Jun | -5.06140 | 2.47830 |
| WM-115 | 48 | hr | p-cJun(S63) | -3.44270 | 3.90520 |
| WM-115 | 48 | hr | p-P38(T180/Y182) | 2.57200 | 2.79880 |
| WM-115 | 48 | hr | p-HSP27(S82) | 0.52233 | 2.75450 |