PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 48 | hr | p-NFKB(S536) | 1.74110 | 3.35930 |
| WM-115 | 48 | hr | Bim | -3.49550 | 3.01040 |
| WM-115 | 48 | hr | cPARP | -3.18320 | 1.24670 |
| WM-115 | 48 | hr | p-Histone H3(S10) | 8.96530 | 1.54730 |
| WM-115 | 48 | hr | p27 Kip1 | -2.93940 | 2.54100 |
| WM1552C | 1 | hr | p-p90RSK(S380) | 3.28960 | -1.18130 |
| WM1552C | 1 | hr | p-p90RSK(T573) | 2.88470 | -0.62720 |
| WM1552C | 1 | hr | p-AKT(T308) | 1.88800 | -1.58740 |
| WM1552C | 1 | hr | p-AKT(S473) | 1.14920 | -1.09220 |
| WM1552C | 1 | hr | p-mTOR(S2448) | 3.76830 | -1.23060 |
| WM1552C | 1 | hr | p-p70S6K(T421/S424) | 3.73010 | -1.50190 |
| WM1552C | 1 | hr | p-p70S6K(T389) | 3.53240 | -1.46320 |
| WM1552C | 1 | hr | p-S6(S235/236) | 1.66360 | -0.46491 |
| WM1552C | 1 | hr | p-AMPK(T172) | 3.88070 | -1.32480 |
| WM1552C | 1 | hr | p-JNK(T183/Y185) | 3.58980 | -1.48600 |
| WM1552C | 1 | hr | Total c-Jun | 3.15050 | -1.30800 |
| WM1552C | 1 | hr | p-cJun(S63) | 3.13890 | -0.89675 |
| WM1552C | 1 | hr | p-P38(T180/Y182) | 3.76720 | -1.92790 |
| WM1552C | 1 | hr | p-HSP27(S82) | 3.54930 | -0.06026 |
| WM1552C | 1 | hr | p-NFKB(S536) | 2.74500 | -1.47240 |
| WM1552C | 1 | hr | Bim | 3.87550 | -1.94590 |
| WM1552C | 1 | hr | cPARP | 3.84930 | -1.84180 |
| WM1552C | 1 | hr | p-Histone H3(S10) | 1.35210 | -0.94734 |
| WM1552C | 1 | hr | p27 Kip1 | 2.88690 | -1.27120 |
| WM1552C | 5 | hr | p-p90RSK(S380) | -1.40520 | 0.28846 |