PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 5 | hr | p-p90RSK(T573) | -1.11420 | 0.92403 |
| WM1552C | 5 | hr | p-AKT(T308) | -1.86920 | -0.12278 |
| WM1552C | 5 | hr | p-AKT(S473) | -2.03990 | -0.23370 |
| WM1552C | 5 | hr | p-mTOR(S2448) | -0.90322 | 0.19896 |
| WM1552C | 5 | hr | p-p70S6K(T421/S424) | -1.56230 | -1.08940 |
| WM1552C | 5 | hr | p-p70S6K(T389) | -1.87510 | -0.17842 |
| WM1552C | 5 | hr | p-S6(S235/236) | -2.75430 | 0.74334 |
| WM1552C | 5 | hr | p-AMPK(T172) | -3.02320 | -0.22848 |
| WM1552C | 5 | hr | p-JNK(T183/Y185) | -1.38780 | 0.27630 |
| WM1552C | 5 | hr | Total c-Jun | 2.56850 | 0.90769 |
| WM1552C | 5 | hr | p-cJun(S63) | 1.24460 | 1.07860 |
| WM1552C | 5 | hr | p-P38(T180/Y182) | -2.27120 | -0.68624 |
| WM1552C | 5 | hr | p-HSP27(S82) | 0.45139 | 1.60980 |
| WM1552C | 5 | hr | p-NFKB(S536) | -1.71710 | 0.27134 |
| WM1552C | 5 | hr | Bim | -2.38430 | -1.02820 |
| WM1552C | 5 | hr | cPARP | -2.69300 | -0.60963 |
| WM1552C | 5 | hr | p-Histone H3(S10) | -1.49050 | -0.31637 |
| WM1552C | 5 | hr | p27 Kip1 | 1.03760 | 0.27832 |
| WM1552C | 10 | hr | p-p90RSK(S380) | 2.09060 | -2.26740 |
| WM1552C | 10 | hr | p-p90RSK(T573) | 2.35780 | -1.33030 |
| WM1552C | 10 | hr | p-AKT(T308) | -0.66148 | -2.55460 |
| WM1552C | 10 | hr | p-AKT(S473) | 0.07012 | -2.47900 |
| WM1552C | 10 | hr | p-mTOR(S2448) | 2.63410 | -1.59050 |
| WM1552C | 10 | hr | p-p70S6K(T421/S424) | 2.31340 | -2.16600 |
| WM1552C | 10 | hr | p-p70S6K(T389) | 2.36010 | -2.27460 |