PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 10 | hr | p-S6(S235/236) | 0.48481 | -0.67677 |
| WM1552C | 10 | hr | p-AMPK(T172) | 1.36010 | -3.12560 |
| WM1552C | 10 | hr | p-JNK(T183/Y185) | 2.51800 | -2.00740 |
| WM1552C | 10 | hr | Total c-Jun | 6.31280 | -0.37565 |
| WM1552C | 10 | hr | p-cJun(S63) | 3.84790 | -1.20420 |
| WM1552C | 10 | hr | p-P38(T180/Y182) | 1.78580 | -2.49710 |
| WM1552C | 10 | hr | p-HSP27(S82) | 1.72630 | -1.51810 |
| WM1552C | 10 | hr | p-NFKB(S536) | 1.73040 | -1.62780 |
| WM1552C | 10 | hr | Bim | 0.93921 | -3.66860 |
| WM1552C | 10 | hr | cPARP | 1.93500 | -2.66780 |
| WM1552C | 10 | hr | p-Histone H3(S10) | 0.64428 | -1.19470 |
| WM1552C | 10 | hr | p27 Kip1 | 4.16310 | -0.56785 |
| WM1552C | 24 | hr | p-p90RSK(S380) | 0.16938 | -1.44560 |
| WM1552C | 24 | hr | p-p90RSK(T573) | -0.70006 | -1.34680 |
| WM1552C | 24 | hr | p-AKT(T308) | -1.49820 | -3.08970 |
| WM1552C | 24 | hr | p-AKT(S473) | -2.18420 | -2.03110 |
| WM1552C | 24 | hr | p-mTOR(S2448) | 0.68143 | -0.84652 |
| WM1552C | 24 | hr | p-p70S6K(T421/S424) | -0.33609 | -1.91060 |
| WM1552C | 24 | hr | p-p70S6K(T389) | -0.00562 | -1.92970 |
| WM1552C | 24 | hr | p-S6(S235/236) | -5.86750 | -1.83620 |
| WM1552C | 24 | hr | p-AMPK(T172) | -0.74530 | -1.73420 |
| WM1552C | 24 | hr | p-JNK(T183/Y185) | -0.21384 | -1.41380 |
| WM1552C | 24 | hr | Total c-Jun | 1.67020 | -0.77903 |
| WM1552C | 24 | hr | p-cJun(S63) | -2.86530 | -2.56720 |
| WM1552C | 24 | hr | p-P38(T180/Y182) | -0.68461 | -1.51280 |