PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 1 | hr | p-AKT(S473) | 0.80356 | -0.61230 |
| MMAC-SF | 1 | hr | p-mTOR(S2448) | 1.15340 | -0.47949 |
| MMAC-SF | 1 | hr | p-p70S6K(T421/S424) | 1.51450 | -0.68034 |
| MMAC-SF | 1 | hr | p-p70S6K(T389) | 1.34210 | -0.33989 |
| MMAC-SF | 1 | hr | p-S6(S235/236) | 2.13560 | -0.30423 |
| MMAC-SF | 1 | hr | p-AMPK(T172) | 1.59160 | -0.75389 |
| MMAC-SF | 1 | hr | p-JNK(T183/Y185) | 1.60870 | -0.38820 |
| MMAC-SF | 1 | hr | Total c-Jun | 2.02800 | -0.26779 |
| MMAC-SF | 1 | hr | p-cJun(S63) | 1.38890 | -0.50336 |
| MMAC-SF | 1 | hr | p-P38(T180/Y182) | 2.19250 | -0.31116 |
| MMAC-SF | 1 | hr | p-HSP27(S82) | 1.24290 | -0.21050 |
| MMAC-SF | 1 | hr | p-NFKB(S536) | 0.92609 | -0.56968 |
| MMAC-SF | 1 | hr | Bim | 1.44370 | -0.88061 |
| MMAC-SF | 1 | hr | cPARP | 1.17690 | -0.40830 |
| MMAC-SF | 1 | hr | p-Histone H3(S10) | 1.14220 | -0.52264 |
| MMAC-SF | 1 | hr | p27 Kip1 | 0.98792 | -0.46810 |
| MMAC-SF | 5 | hr | pMEK(S217/221) | 2.07790 | -1.98240 |
| MMAC-SF | 5 | hr | pERK(T202/Y204) | 7.14050 | 0.54047 |
| MMAC-SF | 5 | hr | p-p90RSK(S380) | -0.78218 | 0.02250 |
| MMAC-SF | 5 | hr | p-p90RSK(T573) | -1.04910 | 0.02695 |
| MMAC-SF | 5 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 5 | hr | p-AKT(S473) | -1.95610 | 0.00422 |
| MMAC-SF | 5 | hr | p-mTOR(S2448) | -1.09970 | -0.17807 |
| MMAC-SF | 5 | hr | p-p70S6K(T421/S424) | -0.83414 | -0.17097 |
| MMAC-SF | 5 | hr | p-p70S6K(T389) | -0.88681 | -0.14100 |