PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 48 | hr | pERK(T202/Y204) | 1.87120 | -1.79890 |
| LOXIMVI | 48 | hr | p-p90RSK(S380) | 0.62773 | -0.21142 |
| LOXIMVI | 48 | hr | p-p90RSK(T573) | 0.07922 | 0.01800 |
| LOXIMVI | 48 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 48 | hr | p-AKT(S473) | 0.88994 | -0.50061 |
| LOXIMVI | 48 | hr | p-mTOR(S2448) | 0.45549 | -0.25390 |
| LOXIMVI | 48 | hr | p-p70S6K(T421/S424) | 1.06240 | -0.65301 |
| LOXIMVI | 48 | hr | p-p70S6K(T389) | 1.58340 | -0.57849 |
| LOXIMVI | 48 | hr | p-S6(S235/236) | -1.13700 | 0.97235 |
| LOXIMVI | 48 | hr | p-AMPK(T172) | -0.34394 | 0.15956 |
| LOXIMVI | 48 | hr | p-JNK(T183/Y185) | 0.35269 | -0.20453 |
| LOXIMVI | 48 | hr | Total c-Jun | 0.93653 | -0.48173 |
| LOXIMVI | 48 | hr | p-cJun(S63) | -0.81107 | 0.31879 |
| LOXIMVI | 48 | hr | p-P38(T180/Y182) | 0.55760 | -0.70329 |
| LOXIMVI | 48 | hr | p-HSP27(S82) | 0.20214 | -0.39637 |
| LOXIMVI | 48 | hr | p-NFKB(S536) | -0.12414 | 0.32225 |
| LOXIMVI | 48 | hr | Bim | -0.27225 | 0.23660 |
| LOXIMVI | 48 | hr | cPARP | 0.03579 | -0.12226 |
| LOXIMVI | 48 | hr | p-Histone H3(S10) | 3.33830 | -1.13670 |
| LOXIMVI | 48 | hr | p27 Kip1 | -0.37980 | 0.06956 |
| MMAC-SF | 1 | hr | pMEK(S217/221) | 4.16280 | -2.59440 |
| MMAC-SF | 1 | hr | pERK(T202/Y204) | 9.37190 | 0.05218 |
| MMAC-SF | 1 | hr | p-p90RSK(S380) | 1.79680 | -0.50825 |
| MMAC-SF | 1 | hr | p-p90RSK(T573) | 1.36650 | -0.40260 |
| MMAC-SF | 1 | hr | p-AKT(T308) | NaN | NaN |