PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 1 | hr | pMEK(S217/221) | 2.91970 | -1.00720 |
| C32 | 1 | hr | pERK(T202/Y204) | 7.43140 | -1.21070 |
| C32 | 1 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 1 | hr | p-p90RSK(T573) | -0.05916 | 0.10315 |
| C32 | 1 | hr | p-AKT(T308) | 0.07270 | -0.43501 |
| C32 | 1 | hr | p-AKT(S473) | -0.22820 | -0.58166 |
| C32 | 1 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 1 | hr | p-p70S6K(T421/S424) | 0.45992 | -0.41066 |
| C32 | 1 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 1 | hr | p-S6(S235/236) | 1.41460 | -0.44037 |
| C32 | 1 | hr | p-AMPK(T172) | -0.18447 | -0.16975 |
| C32 | 1 | hr | p-JNK(T183/Y185) | 0.37130 | -0.99243 |
| C32 | 1 | hr | Total c-Jun | 0.54181 | 0.04245 |
| C32 | 1 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 1 | hr | p-P38(T180/Y182) | 0.41981 | -0.31632 |
| C32 | 1 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 1 | hr | p-NFKB(S536) | 0.49350 | -0.08939 |
| C32 | 1 | hr | Bim | -0.02802 | -0.10082 |
| C32 | 1 | hr | cPARP | 0.35603 | -0.28605 |
| C32 | 1 | hr | p-Histone H3(S10) | -0.59038 | 0.58833 |
| C32 | 1 | hr | p27 Kip1 | 0.10111 | -0.06938 |
| C32 | 5 | hr | pMEK(S217/221) | 2.90920 | -1.19320 |
| C32 | 5 | hr | pERK(T202/Y204) | 6.85300 | 0.56211 |
| C32 | 5 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 5 | hr | p-p90RSK(T573) | -0.50929 | -0.16568 |