PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| RVH-421 | 1 | hr | p27 Kip1 | 2.45490 | -1.11690 |
| RVH-421 | 5 | hr | pMEK(S217/221) | 3.00250 | -2.02300 |
| RVH-421 | 5 | hr | pERK(T202/Y204) | 10.76400 | -0.55973 |
| RVH-421 | 5 | hr | p-p90RSK(S380) | -1.39370 | -0.60339 |
| RVH-421 | 5 | hr | p-p90RSK(T573) | -1.70410 | -0.80056 |
| RVH-421 | 5 | hr | p-AKT(T308) | -1.02840 | -0.60449 |
| RVH-421 | 5 | hr | p-AKT(S473) | -1.30540 | -0.54099 |
| RVH-421 | 5 | hr | p-mTOR(S2448) | -1.55480 | -0.86222 |
| RVH-421 | 5 | hr | p-p70S6K(T421/S424) | 0.25861 | -0.06213 |
| RVH-421 | 5 | hr | p-p70S6K(T389) | -1.49780 | -0.87984 |
| RVH-421 | 5 | hr | p-S6(S235/236) | 1.85750 | -0.46610 |
| RVH-421 | 5 | hr | p-AMPK(T172) | -2.43460 | -0.90404 |
| RVH-421 | 5 | hr | p-JNK(T183/Y185) | NaN | NaN |
| RVH-421 | 5 | hr | Total c-Jun | -0.20031 | 0.96880 |
| RVH-421 | 5 | hr | p-cJun(S63) | 0.09333 | 0.13883 |
| RVH-421 | 5 | hr | p-P38(T180/Y182) | 0.25850 | 0.66883 |
| RVH-421 | 5 | hr | p-HSP27(S82) | -2.10070 | -1.10050 |
| RVH-421 | 5 | hr | p-NFKB(S536) | -2.44820 | -1.80680 |
| RVH-421 | 5 | hr | Bim | -1.93750 | -1.47170 |
| RVH-421 | 5 | hr | cPARP | -3.52540 | -1.15470 |
| RVH-421 | 5 | hr | p-Histone H3(S10) | -3.28910 | -1.52710 |
| RVH-421 | 5 | hr | p27 Kip1 | -2.18590 | -0.88099 |
| RVH-421 | 10 | hr | pMEK(S217/221) | 7.56990 | -1.43780 |
| RVH-421 | 10 | hr | pERK(T202/Y204) | 9.25760 | 0.99468 |
| RVH-421 | 10 | hr | p-p90RSK(S380) | 1.39650 | -0.46987 |