PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| RVH-421 | 10 | hr | p-p90RSK(T573) | 1.50620 | -0.54149 |
| RVH-421 | 10 | hr | p-AKT(T308) | 1.04510 | -0.51847 |
| RVH-421 | 10 | hr | p-AKT(S473) | 1.26460 | -0.50097 |
| RVH-421 | 10 | hr | p-mTOR(S2448) | 1.76760 | -0.68234 |
| RVH-421 | 10 | hr | p-p70S6K(T421/S424) | 1.40800 | 0.05064 |
| RVH-421 | 10 | hr | p-p70S6K(T389) | 1.77060 | -0.77143 |
| RVH-421 | 10 | hr | p-S6(S235/236) | 7.93520 | -0.67412 |
| RVH-421 | 10 | hr | p-AMPK(T172) | 3.22610 | -0.59945 |
| RVH-421 | 10 | hr | p-JNK(T183/Y185) | NaN | NaN |
| RVH-421 | 10 | hr | Total c-Jun | -2.50660 | 1.53710 |
| RVH-421 | 10 | hr | p-cJun(S63) | -0.10238 | 0.09569 |
| RVH-421 | 10 | hr | p-P38(T180/Y182) | -0.23080 | 0.41844 |
| RVH-421 | 10 | hr | p-HSP27(S82) | 2.23340 | -0.55536 |
| RVH-421 | 10 | hr | p-NFKB(S536) | 0.95507 | -0.46298 |
| RVH-421 | 10 | hr | Bim | 1.27140 | -1.19990 |
| RVH-421 | 10 | hr | cPARP | 0.96902 | -0.94620 |
| RVH-421 | 10 | hr | p-Histone H3(S10) | 0.32840 | -0.76121 |
| RVH-421 | 10 | hr | p27 Kip1 | 1.82250 | -0.77954 |
| RVH-421 | 24 | hr | pMEK(S217/221) | 3.15880 | -2.18250 |
| RVH-421 | 24 | hr | pERK(T202/Y204) | 7.88390 | 0.63578 |
| RVH-421 | 24 | hr | p-p90RSK(S380) | -1.48700 | -0.60143 |
| RVH-421 | 24 | hr | p-p90RSK(T573) | -1.64620 | -0.78839 |
| RVH-421 | 24 | hr | p-AKT(T308) | -0.60904 | -0.37257 |
| RVH-421 | 24 | hr | p-AKT(S473) | -0.11125 | -0.04547 |
| RVH-421 | 24 | hr | p-mTOR(S2448) | -1.03560 | -0.81762 |