PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| RVH-421 | 24 | hr | p-p70S6K(T421/S424) | 1.34320 | 0.17333 |
| RVH-421 | 24 | hr | p-p70S6K(T389) | -1.23870 | -0.72439 |
| RVH-421 | 24 | hr | p-S6(S235/236) | 4.35000 | 0.28838 |
| RVH-421 | 24 | hr | p-AMPK(T172) | -2.34250 | -1.33550 |
| RVH-421 | 24 | hr | p-JNK(T183/Y185) | NaN | NaN |
| RVH-421 | 24 | hr | Total c-Jun | -5.50660 | 0.85027 |
| RVH-421 | 24 | hr | p-cJun(S63) | -0.52074 | 0.20948 |
| RVH-421 | 24 | hr | p-P38(T180/Y182) | -0.81514 | 1.05650 |
| RVH-421 | 24 | hr | p-HSP27(S82) | -2.11000 | -1.01410 |
| RVH-421 | 24 | hr | p-NFKB(S536) | -3.03370 | -1.27460 |
| RVH-421 | 24 | hr | Bim | -2.11430 | -1.30900 |
| RVH-421 | 24 | hr | cPARP | -9.33010 | -1.03280 |
| RVH-421 | 24 | hr | p-Histone H3(S10) | 1.74570 | 0.00946 |
| RVH-421 | 24 | hr | p27 Kip1 | -3.81390 | -1.51440 |
| RVH-421 | 48 | hr | pMEK(S217/221) | 5.64600 | -2.20290 |
| RVH-421 | 48 | hr | pERK(T202/Y204) | 9.55160 | -2.13990 |
| RVH-421 | 48 | hr | p-p90RSK(S380) | -0.91449 | -0.32544 |
| RVH-421 | 48 | hr | p-p90RSK(T573) | -1.05990 | -0.92889 |
| RVH-421 | 48 | hr | p-AKT(T308) | -0.92826 | -0.34009 |
| RVH-421 | 48 | hr | p-AKT(S473) | 0.52397 | -0.34457 |
| RVH-421 | 48 | hr | p-mTOR(S2448) | -0.47362 | -0.61351 |
| RVH-421 | 48 | hr | p-p70S6K(T421/S424) | 1.09500 | -0.03397 |
| RVH-421 | 48 | hr | p-p70S6K(T389) | -1.19580 | -0.89246 |
| RVH-421 | 48 | hr | p-S6(S235/236) | 2.99300 | -1.48290 |
| RVH-421 | 48 | hr | p-AMPK(T172) | -0.08255 | -1.23710 |