PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 5 | hr | p-S6(S235/236) | 1.79610 | 0.34708 |
| MMAC-SF | 5 | hr | p-AMPK(T172) | -1.44650 | -0.15278 |
| MMAC-SF | 5 | hr | p-JNK(T183/Y185) | -1.37220 | 0.11091 |
| MMAC-SF | 5 | hr | Total c-Jun | 0.83701 | 0.18951 |
| MMAC-SF | 5 | hr | p-cJun(S63) | -1.53820 | -0.28003 |
| MMAC-SF | 5 | hr | p-P38(T180/Y182) | -0.67267 | 0.13878 |
| MMAC-SF | 5 | hr | p-HSP27(S82) | -1.57330 | -0.09548 |
| MMAC-SF | 5 | hr | p-NFKB(S536) | -0.68588 | -0.15650 |
| MMAC-SF | 5 | hr | Bim | -2.45940 | -0.04915 |
| MMAC-SF | 5 | hr | cPARP | -1.24420 | -0.08587 |
| MMAC-SF | 5 | hr | p-Histone H3(S10) | -1.12090 | -0.11665 |
| MMAC-SF | 5 | hr | p27 Kip1 | -1.01100 | -0.33309 |
| MMAC-SF | 10 | hr | pMEK(S217/221) | 4.18770 | -2.30410 |
| MMAC-SF | 10 | hr | pERK(T202/Y204) | 9.42510 | 0.15903 |
| MMAC-SF | 10 | hr | p-p90RSK(S380) | 1.45000 | -0.43077 |
| MMAC-SF | 10 | hr | p-p90RSK(T573) | 0.81177 | -0.87475 |
| MMAC-SF | 10 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 10 | hr | p-AKT(S473) | 0.63469 | -0.56465 |
| MMAC-SF | 10 | hr | p-mTOR(S2448) | 1.13760 | -0.36454 |
| MMAC-SF | 10 | hr | p-p70S6K(T421/S424) | 1.30450 | -0.53661 |
| MMAC-SF | 10 | hr | p-p70S6K(T389) | 1.16370 | -0.22130 |
| MMAC-SF | 10 | hr | p-S6(S235/236) | 5.73150 | 0.32290 |
| MMAC-SF | 10 | hr | p-AMPK(T172) | 1.88310 | -0.30100 |
| MMAC-SF | 10 | hr | p-JNK(T183/Y185) | 1.36490 | -0.43868 |
| MMAC-SF | 10 | hr | Total c-Jun | 3.47900 | -0.24757 |