PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 10 | hr | p-cJun(S63) | 1.25820 | -0.61620 |
| MMAC-SF | 10 | hr | p-P38(T180/Y182) | 1.59850 | 0.06695 |
| MMAC-SF | 10 | hr | p-HSP27(S82) | 0.50225 | -0.29830 |
| MMAC-SF | 10 | hr | p-NFKB(S536) | 1.88630 | -0.31242 |
| MMAC-SF | 10 | hr | Bim | 0.63646 | -0.74968 |
| MMAC-SF | 10 | hr | cPARP | 0.13707 | -0.61833 |
| MMAC-SF | 10 | hr | p-Histone H3(S10) | -0.19180 | -0.40155 |
| MMAC-SF | 10 | hr | p27 Kip1 | 0.85002 | -0.50126 |
| MMAC-SF | 24 | hr | pMEK(S217/221) | 1.90460 | -1.35000 |
| MMAC-SF | 24 | hr | pERK(T202/Y204) | 4.96270 | 1.18870 |
| MMAC-SF | 24 | hr | p-p90RSK(S380) | -0.59234 | 0.22698 |
| MMAC-SF | 24 | hr | p-p90RSK(T573) | -0.35999 | -0.09492 |
| MMAC-SF | 24 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 24 | hr | p-AKT(S473) | -2.66610 | 0.08923 |
| MMAC-SF | 24 | hr | p-mTOR(S2448) | -1.29080 | -0.01975 |
| MMAC-SF | 24 | hr | p-p70S6K(T421/S424) | -0.64370 | 0.04641 |
| MMAC-SF | 24 | hr | p-p70S6K(T389) | -1.15930 | 0.10684 |
| MMAC-SF | 24 | hr | p-S6(S235/236) | 5.79410 | 1.68960 |
| MMAC-SF | 24 | hr | p-AMPK(T172) | -1.75070 | 0.15251 |
| MMAC-SF | 24 | hr | p-JNK(T183/Y185) | -2.26180 | 0.20239 |
| MMAC-SF | 24 | hr | Total c-Jun | -0.75332 | 0.20352 |
| MMAC-SF | 24 | hr | p-cJun(S63) | -2.88630 | 0.01569 |
| MMAC-SF | 24 | hr | p-P38(T180/Y182) | -2.01300 | 0.08904 |
| MMAC-SF | 24 | hr | p-HSP27(S82) | -2.65220 | 0.12816 |
| MMAC-SF | 24 | hr | p-NFKB(S536) | -0.98649 | -0.05127 |