PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 1 | hr | p-AKT(S473) | 0.54488 | -0.76362 |
| WM1552C | 1 | hr | p-mTOR(S2448) | 1.42720 | -0.75908 |
| WM1552C | 1 | hr | p-p70S6K(T421/S424) | 1.55300 | -0.99489 |
| WM1552C | 1 | hr | p-p70S6K(T389) | 1.58340 | -1.08260 |
| WM1552C | 1 | hr | p-S6(S235/236) | 0.65080 | -0.57446 |
| WM1552C | 1 | hr | p-AMPK(T172) | 1.33620 | -0.67454 |
| WM1552C | 1 | hr | p-JNK(T183/Y185) | 1.45770 | -0.91981 |
| WM1552C | 1 | hr | Total c-Jun | 1.52170 | -0.87160 |
| WM1552C | 1 | hr | p-cJun(S63) | 1.42020 | -0.81236 |
| WM1552C | 1 | hr | p-P38(T180/Y182) | 1.48000 | -1.06630 |
| WM1552C | 1 | hr | p-HSP27(S82) | 1.54350 | -0.46652 |
| WM1552C | 1 | hr | p-NFKB(S536) | 1.18080 | -0.92854 |
| WM1552C | 1 | hr | Bim | 1.71290 | -1.30780 |
| WM1552C | 1 | hr | cPARP | 1.41200 | -0.99897 |
| WM1552C | 1 | hr | p-Histone H3(S10) | 1.14410 | -1.04180 |
| WM1552C | 1 | hr | p27 Kip1 | 1.41690 | -0.90408 |
| WM1552C | 5 | hr | pMEK(S217/221) | 2.41470 | -1.13790 |
| WM1552C | 5 | hr | pERK(T202/Y204) | 7.39710 | 0.80643 |
| WM1552C | 5 | hr | p-p90RSK(S380) | -0.25597 | -0.42339 |
| WM1552C | 5 | hr | p-p90RSK(T573) | -0.13343 | -0.17898 |
| WM1552C | 5 | hr | p-AKT(T308) | -0.78872 | -0.83332 |
| WM1552C | 5 | hr | p-AKT(S473) | -0.90432 | -0.67135 |
| WM1552C | 5 | hr | p-mTOR(S2448) | -0.10469 | -0.60573 |
| WM1552C | 5 | hr | p-p70S6K(T421/S424) | -0.48323 | -1.20100 |
| WM1552C | 5 | hr | p-p70S6K(T389) | -0.59739 | -0.86903 |