PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 5 | hr | p-S6(S235/236) | -0.73607 | -0.24720 |
| WM1552C | 5 | hr | p-AMPK(T172) | -0.90466 | -0.56141 |
| WM1552C | 5 | hr | p-JNK(T183/Y185) | -0.26746 | -0.69956 |
| WM1552C | 5 | hr | Total c-Jun | 1.58970 | -0.20117 |
| WM1552C | 5 | hr | p-cJun(S63) | 0.89778 | -0.32381 |
| WM1552C | 5 | hr | p-P38(T180/Y182) | -0.72553 | -0.95401 |
| WM1552C | 5 | hr | p-HSP27(S82) | 0.59308 | -0.32984 |
| WM1552C | 5 | hr | p-NFKB(S536) | -0.51668 | -0.58352 |
| WM1552C | 5 | hr | Bim | -0.94622 | -1.25560 |
| WM1552C | 5 | hr | cPARP | -0.85600 | -0.84695 |
| WM1552C | 5 | hr | p-Histone H3(S10) | -1.09250 | -0.92409 |
| WM1552C | 5 | hr | p27 Kip1 | 0.77875 | -0.53953 |
| WM1552C | 10 | hr | pMEK(S217/221) | 3.50460 | -1.59200 |
| WM1552C | 10 | hr | pERK(T202/Y204) | 8.95630 | 0.51497 |
| WM1552C | 10 | hr | p-p90RSK(S380) | 0.60489 | -0.95333 |
| WM1552C | 10 | hr | p-p90RSK(T573) | 0.76506 | -0.67646 |
| WM1552C | 10 | hr | p-AKT(T308) | -0.45227 | -1.80160 |
| WM1552C | 10 | hr | p-AKT(S473) | -0.14843 | -1.44760 |
| WM1552C | 10 | hr | p-mTOR(S2448) | 0.99032 | -0.89242 |
| WM1552C | 10 | hr | p-p70S6K(T421/S424) | 0.88426 | -1.09950 |
| WM1552C | 10 | hr | p-p70S6K(T389) | 0.96434 | -1.23780 |
| WM1552C | 10 | hr | p-S6(S235/236) | 0.22695 | -0.57897 |
| WM1552C | 10 | hr | p-AMPK(T172) | 0.31773 | -1.17560 |
| WM1552C | 10 | hr | p-JNK(T183/Y185) | 1.00960 | -1.10880 |
| WM1552C | 10 | hr | Total c-Jun | 3.25640 | -0.60574 |