PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 48 | hr | p-NFKB(S536) | -0.23740 | 0.10188 |
| MZ7-mel | 48 | hr | Bim | -3.54030 | 0.06996 |
| MZ7-mel | 48 | hr | cPARP | -2.37610 | 0.44509 |
| MZ7-mel | 48 | hr | p-Histone H3(S10) | 8.05000 | -0.66270 |
| MZ7-mel | 48 | hr | p27 Kip1 | -3.80790 | 0.37888 |
| RVH-421 | 1 | hr | pMEK(S217/221) | 6.98480 | -2.31590 |
| RVH-421 | 1 | hr | pERK(T202/Y204) | 11.07000 | 1.99010 |
| RVH-421 | 1 | hr | p-p90RSK(S380) | 0.62273 | -0.16431 |
| RVH-421 | 1 | hr | p-p90RSK(T573) | 0.71190 | -0.44012 |
| RVH-421 | 1 | hr | p-AKT(T308) | 0.67727 | -0.37475 |
| RVH-421 | 1 | hr | p-AKT(S473) | 0.50499 | -0.32393 |
| RVH-421 | 1 | hr | p-mTOR(S2448) | 0.89714 | -0.41748 |
| RVH-421 | 1 | hr | p-p70S6K(T421/S424) | 1.06860 | 0.02069 |
| RVH-421 | 1 | hr | p-p70S6K(T389) | 1.05630 | -0.38315 |
| RVH-421 | 1 | hr | p-S6(S235/236) | 2.41430 | -0.91381 |
| RVH-421 | 1 | hr | p-AMPK(T172) | 2.73070 | -1.21180 |
| RVH-421 | 1 | hr | p-JNK(T183/Y185) | NaN | NaN |
| RVH-421 | 1 | hr | Total c-Jun | -0.00488 | 0.67404 |
| RVH-421 | 1 | hr | p-cJun(S63) | -0.42525 | 0.02977 |
| RVH-421 | 1 | hr | p-P38(T180/Y182) | 0.87451 | 0.75721 |
| RVH-421 | 1 | hr | p-HSP27(S82) | 2.36660 | -0.56521 |
| RVH-421 | 1 | hr | p-NFKB(S536) | 2.48700 | -1.08470 |
| RVH-421 | 1 | hr | Bim | 1.01960 | -1.11040 |
| RVH-421 | 1 | hr | cPARP | 2.67800 | -0.53621 |
| RVH-421 | 1 | hr | p-Histone H3(S10) | 2.19800 | -1.62730 |