PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 24 | hr | Total c-Jun | 0.35368 | -0.13091 |
| MZ7-mel | 24 | hr | p-cJun(S63) | -0.71774 | -0.50704 |
| MZ7-mel | 24 | hr | p-P38(T180/Y182) | 0.55536 | -0.58599 |
| MZ7-mel | 24 | hr | p-HSP27(S82) | -0.75219 | -0.46691 |
| MZ7-mel | 24 | hr | p-NFKB(S536) | -0.30454 | -0.41873 |
| MZ7-mel | 24 | hr | Bim | -2.69420 | -0.86827 |
| MZ7-mel | 24 | hr | cPARP | -2.07020 | -0.32862 |
| MZ7-mel | 24 | hr | p-Histone H3(S10) | 2.07310 | 0.67005 |
| MZ7-mel | 24 | hr | p27 Kip1 | -3.44280 | -0.48346 |
| MZ7-mel | 48 | hr | pMEK(S217/221) | 4.13770 | -0.93482 |
| MZ7-mel | 48 | hr | pERK(T202/Y204) | 6.76800 | -0.09975 |
| MZ7-mel | 48 | hr | p-p90RSK(S380) | 0.10522 | 0.25677 |
| MZ7-mel | 48 | hr | p-p90RSK(T573) | 2.39150 | 0.04559 |
| MZ7-mel | 48 | hr | p-AKT(T308) | -1.05770 | 0.10060 |
| MZ7-mel | 48 | hr | p-AKT(S473) | -0.28062 | 0.11150 |
| MZ7-mel | 48 | hr | p-mTOR(S2448) | -0.92420 | 0.20604 |
| MZ7-mel | 48 | hr | p-p70S6K(T421/S424) | 0.65320 | 0.15205 |
| MZ7-mel | 48 | hr | p-p70S6K(T389) | -0.92399 | -0.05149 |
| MZ7-mel | 48 | hr | p-S6(S235/236) | 5.14400 | -0.37396 |
| MZ7-mel | 48 | hr | p-AMPK(T172) | -0.16716 | 0.49452 |
| MZ7-mel | 48 | hr | p-JNK(T183/Y185) | -0.36577 | 0.38501 |
| MZ7-mel | 48 | hr | Total c-Jun | -0.13245 | 0.31781 |
| MZ7-mel | 48 | hr | p-cJun(S63) | -0.76090 | 0.22933 |
| MZ7-mel | 48 | hr | p-P38(T180/Y182) | 0.90168 | 0.37563 |
| MZ7-mel | 48 | hr | p-HSP27(S82) | -0.60791 | 0.15160 |