PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 1 | hr | p-AMPK(T172) | 0.58540 | 1.03210 |
| WM-115 | 1 | hr | p-JNK(T183/Y185) | 1.71420 | 0.35645 |
| WM-115 | 1 | hr | Total c-Jun | 2.15800 | 0.20979 |
| WM-115 | 1 | hr | p-cJun(S63) | 0.88454 | 0.89004 |
| WM-115 | 1 | hr | p-P38(T180/Y182) | 1.55660 | 0.03620 |
| WM-115 | 1 | hr | p-HSP27(S82) | -0.31859 | 0.16494 |
| WM-115 | 1 | hr | p-NFKB(S536) | 0.31070 | 0.63499 |
| WM-115 | 1 | hr | Bim | 1.09860 | 1.08640 |
| WM-115 | 1 | hr | cPARP | 0.45668 | 0.47791 |
| WM-115 | 1 | hr | p-Histone H3(S10) | 0.31209 | 1.08030 |
| WM-115 | 1 | hr | p27 Kip1 | 0.74185 | 1.19150 |
| WM-115 | 5 | hr | pMEK(S217/221) | 2.24650 | -0.31879 |
| WM-115 | 5 | hr | pERK(T202/Y204) | 5.11570 | 1.23480 |
| WM-115 | 5 | hr | p-p90RSK(S380) | 0.71722 | 0.35797 |
| WM-115 | 5 | hr | p-p90RSK(T573) | -0.15418 | 0.07814 |
| WM-115 | 5 | hr | p-AKT(T308) | -1.97220 | 1.56960 |
| WM-115 | 5 | hr | p-AKT(S473) | -2.07990 | 0.99858 |
| WM-115 | 5 | hr | p-mTOR(S2448) | -0.09595 | 0.70906 |
| WM-115 | 5 | hr | p-p70S6K(T421/S424) | -0.26868 | 0.57301 |
| WM-115 | 5 | hr | p-p70S6K(T389) | -0.25985 | 0.96583 |
| WM-115 | 5 | hr | p-S6(S235/236) | 1.31530 | -0.54324 |
| WM-115 | 5 | hr | p-AMPK(T172) | -0.94110 | 0.99099 |
| WM-115 | 5 | hr | p-JNK(T183/Y185) | -0.60147 | 0.93064 |
| WM-115 | 5 | hr | Total c-Jun | 0.55632 | -0.15090 |
| WM-115 | 5 | hr | p-cJun(S63) | -0.77422 | 0.99435 |